Network Modeling of MDM2 Inhibitor-Oxaliplatin Combination Reveals Biological Synergy in wt-p53 solid tumors

Network Modeling of MDM2 Inhibitor-Oxaliplatin Combination Reveals Biological Synergy in wt-p53 solid tumors

Earlier we had shown that the MDM2 inhibitor (MI-219) belonging to the spiro-oxindole family can synergistically enhance the efficacy of platinum chemotherapeutics leading to 50% tumor free survival in a genetically complex pancreatic ductal adenocarcinoma (PDAC) xenograft model. In this report, we...

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Bibliographic Details
Main Authors: Azmi, Asfar S., Banerjee, Sanjeev, Ali, Shadan, Wang, Zhiwei, Bao, Bin, Beck, Frances W.J., Maitah, Main, Choi, Minsig, Shields, Tony F., Philip, Philip A., Sarkar, Fazlul H., Mohammad, Ramzi M.
Format: Online
Language:English
Published: Impact Journals LLC 2011
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3248191/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3248191/

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