Segmentation of the Pathophysiological Stages of Diabetic Changes in the db/db Mouse

The db/db mouse is one of the diabetes mellitus animal models and if the pathophysiological stages of diabetic changes in the mouse model could simulate the stages in human diabetes, the db/db mouse could be used to better evaluate drug candidates. Blood insulin, HbA1c levels and morphological feat...

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Main Authors:	Yamazaki, Masaki, Kato, Atsuhiko, Kato, Chie, Fujii, Etsuko, Adachi, Kenji, Miyoshi, Akio, Suzuki, Masami
Format:	Online
Language:	English
Published:	The Japanese Society of Toxicologic Pathology 2009
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3246058/

id	pubmed-3246058
recordtype	oai_dc
spelling	pubmed-32460582012-01-23 Segmentation of the Pathophysiological Stages of Diabetic Changes in the db/db Mouse Yamazaki, Masaki Kato, Atsuhiko Kato, Chie Fujii, Etsuko Adachi, Kenji Miyoshi, Akio Suzuki, Masami Original The db/db mouse is one of the diabetes mellitus animal models and if the pathophysiological stages of diabetic changes in the mouse model could simulate the stages in human diabetes, the db/db mouse could be used to better evaluate drug candidates. Blood insulin, HbA1c levels and morphological features of pancreatic islets in db/db mice were evaluated to determine the pathophysiological stage. At 6 weeks of age, db/db mice showed the highest level of plasma insulin and lowest level of HbA1c, and histopathological examination revealed enlarged islets with a circular shape and hypertrophic islet cells. By 9 and 12 weeks of age, the plasma insulin levels had decreased to mid levels and HbA1c had increased to mid to high levels; histopathological examination at this time revealed two types of islets coexisting, enlarged circular islets and small irregular-shaped islets. By 15 and 22 weeks of age, plasma insulin had decreased further to low levels and HbA1c was at its highest level; the histopathological examination at this time revealed an increase in irregular-shaped and small islets. Based on blood insulin levels, HbA1c levels and histopathology findings in the db/db mice in this study, the clinical staging of diabetic changes were recognized. The pathophysiological stages of diabetes mellitus in this animal model were similar to the stages in humans. The Japanese Society of Toxicologic Pathology 2009-07-07 2009-06 /pmc/articles/PMC3246058/ /pubmed/22271986 http://dx.doi.org/10.1293/tox.22.133 Text en ©2009 The Japanese Society of Toxicologic Pathology http://creativecommons.org/licenses/by-nc-nd/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial No Derivatives (by-nc-nd) License.
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Yamazaki, Masaki Kato, Atsuhiko Kato, Chie Fujii, Etsuko Adachi, Kenji Miyoshi, Akio Suzuki, Masami
spellingShingle	Yamazaki, Masaki Kato, Atsuhiko Kato, Chie Fujii, Etsuko Adachi, Kenji Miyoshi, Akio Suzuki, Masami Segmentation of the Pathophysiological Stages of Diabetic Changes in the db/db Mouse
author_facet	Yamazaki, Masaki Kato, Atsuhiko Kato, Chie Fujii, Etsuko Adachi, Kenji Miyoshi, Akio Suzuki, Masami
author_sort	Yamazaki, Masaki
title	Segmentation of the Pathophysiological Stages of Diabetic Changes in the db/db Mouse
title_short	Segmentation of the Pathophysiological Stages of Diabetic Changes in the db/db Mouse
title_full	Segmentation of the Pathophysiological Stages of Diabetic Changes in the db/db Mouse
title_fullStr	Segmentation of the Pathophysiological Stages of Diabetic Changes in the db/db Mouse
title_full_unstemmed	Segmentation of the Pathophysiological Stages of Diabetic Changes in the db/db Mouse
title_sort	segmentation of the pathophysiological stages of diabetic changes in the db/db mouse
description	The db/db mouse is one of the diabetes mellitus animal models and if the pathophysiological stages of diabetic changes in the mouse model could simulate the stages in human diabetes, the db/db mouse could be used to better evaluate drug candidates. Blood insulin, HbA1c levels and morphological features of pancreatic islets in db/db mice were evaluated to determine the pathophysiological stage. At 6 weeks of age, db/db mice showed the highest level of plasma insulin and lowest level of HbA1c, and histopathological examination revealed enlarged islets with a circular shape and hypertrophic islet cells. By 9 and 12 weeks of age, the plasma insulin levels had decreased to mid levels and HbA1c had increased to mid to high levels; histopathological examination at this time revealed two types of islets coexisting, enlarged circular islets and small irregular-shaped islets. By 15 and 22 weeks of age, plasma insulin had decreased further to low levels and HbA1c was at its highest level; the histopathological examination at this time revealed an increase in irregular-shaped and small islets. Based on blood insulin levels, HbA1c levels and histopathology findings in the db/db mice in this study, the clinical staging of diabetic changes were recognized. The pathophysiological stages of diabetes mellitus in this animal model were similar to the stages in humans.
publisher	The Japanese Society of Toxicologic Pathology
publishDate	2009
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3246058/
_version_	1611496545310474240

Segmentation of the Pathophysiological Stages of Diabetic Changes in the db/db Mouse

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