Regulated functional alternative splicing in Drosophila
Alternative splicing expands the coding capacity of metazoan genes, and it was largely genetic studies in the fruit-fly Drosophila melanogaster that established the principle that regulated alternative splicing results in tissue- and stage-specific protein isoforms with different functions in develo...
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| Format: | Online |
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Oxford University Press
2012
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3245913/ |
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pubmed-32459132012-01-03 Regulated functional alternative splicing in Drosophila Venables, Julian P. Tazi, Jamal Juge, François Survey and Summary Alternative splicing expands the coding capacity of metazoan genes, and it was largely genetic studies in the fruit-fly Drosophila melanogaster that established the principle that regulated alternative splicing results in tissue- and stage-specific protein isoforms with different functions in development. Alternative splicing is particularly prominent in germ cells, muscle and the central nervous system where it modulates the expression of various proteins including cell-surface molecules and transcription factors. Studies in flies have given us numerous insights into alternative splicing in terms of upstream regulation, the exquisite diversity of their forms and the key differential cellular functions of alternatively spliced gene products. The current inundation of transcriptome sequencing data from Drosophila provides an unprecedented opportunity to gain a comprehensive view of alternative splicing. Oxford University Press 2012-01 2011-09-08 /pmc/articles/PMC3245913/ /pubmed/21908400 http://dx.doi.org/10.1093/nar/gkr648 Text en © The Author(s) 2011. Published by Oxford University Press. http://creativecommons.org/licenses/by-nc/3.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
| repository_type |
Open Access Journal |
| institution_category |
Foreign Institution |
| institution |
US National Center for Biotechnology Information |
| building |
NCBI PubMed |
| collection |
Online Access |
| language |
English |
| format |
Online |
| author |
Venables, Julian P. Tazi, Jamal Juge, François |
| spellingShingle |
Venables, Julian P. Tazi, Jamal Juge, François Regulated functional alternative splicing in Drosophila |
| author_facet |
Venables, Julian P. Tazi, Jamal Juge, François |
| author_sort |
Venables, Julian P. |
| title |
Regulated functional alternative splicing in Drosophila |
| title_short |
Regulated functional alternative splicing in Drosophila |
| title_full |
Regulated functional alternative splicing in Drosophila |
| title_fullStr |
Regulated functional alternative splicing in Drosophila |
| title_full_unstemmed |
Regulated functional alternative splicing in Drosophila |
| title_sort |
regulated functional alternative splicing in drosophila |
| description |
Alternative splicing expands the coding capacity of metazoan genes, and it was largely genetic studies in the fruit-fly Drosophila melanogaster that established the principle that regulated alternative splicing results in tissue- and stage-specific protein isoforms with different functions in development. Alternative splicing is particularly prominent in germ cells, muscle and the central nervous system where it modulates the expression of various proteins including cell-surface molecules and transcription factors. Studies in flies have given us numerous insights into alternative splicing in terms of upstream regulation, the exquisite diversity of their forms and the key differential cellular functions of alternatively spliced gene products. The current inundation of transcriptome sequencing data from Drosophila provides an unprecedented opportunity to gain a comprehensive view of alternative splicing. |
| publisher |
Oxford University Press |
| publishDate |
2012 |
| url |
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3245913/ |
| _version_ |
1611496510068883456 |