Evolutionary genetic dissection of human interferons

As revealed by population genetic analyses, different human interferon genes evolved under distinct selective constraints and signatures of positive selection vary according to geographic region, suggesting that some sequence changes may have conferred an advantage by increasing resistance to viral...

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Main Authors:	Manry, Jérémy, Laval, Guillaume, Patin, Etienne, Fornarino, Simona, Itan, Yuval, Fumagalli, Matteo, Sironi, Manuela, Tichit, Magali, Bouchier, Christiane, Casanova, Jean-Laurent, Barreiro, Luis B., Quintana-Murci, Lluis
Format:	Online
Language:	English
Published:	The Rockefeller University Press 2011
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3244034/

id	pubmed-3244034
recordtype	oai_dc
spelling	pubmed-32440342012-06-19 Evolutionary genetic dissection of human interferons Manry, Jérémy Laval, Guillaume Patin, Etienne Fornarino, Simona Itan, Yuval Fumagalli, Matteo Sironi, Manuela Tichit, Magali Bouchier, Christiane Casanova, Jean-Laurent Barreiro, Luis B. Quintana-Murci, Lluis Article As revealed by population genetic analyses, different human interferon genes evolved under distinct selective constraints and signatures of positive selection vary according to geographic region, suggesting that some sequence changes may have conferred an advantage by increasing resistance to viral infection. The Rockefeller University Press 2011-12-19 /pmc/articles/PMC3244034/ /pubmed/22162829 http://dx.doi.org/10.1084/jem.20111680 Text en © 2011 Manry et al. This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 3.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/3.0/).
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Manry, Jérémy Laval, Guillaume Patin, Etienne Fornarino, Simona Itan, Yuval Fumagalli, Matteo Sironi, Manuela Tichit, Magali Bouchier, Christiane Casanova, Jean-Laurent Barreiro, Luis B. Quintana-Murci, Lluis
spellingShingle	Manry, Jérémy Laval, Guillaume Patin, Etienne Fornarino, Simona Itan, Yuval Fumagalli, Matteo Sironi, Manuela Tichit, Magali Bouchier, Christiane Casanova, Jean-Laurent Barreiro, Luis B. Quintana-Murci, Lluis Evolutionary genetic dissection of human interferons
author_facet	Manry, Jérémy Laval, Guillaume Patin, Etienne Fornarino, Simona Itan, Yuval Fumagalli, Matteo Sironi, Manuela Tichit, Magali Bouchier, Christiane Casanova, Jean-Laurent Barreiro, Luis B. Quintana-Murci, Lluis
author_sort	Manry, Jérémy
title	Evolutionary genetic dissection of human interferons
title_short	Evolutionary genetic dissection of human interferons
title_full	Evolutionary genetic dissection of human interferons
title_fullStr	Evolutionary genetic dissection of human interferons
title_full_unstemmed	Evolutionary genetic dissection of human interferons
title_sort	evolutionary genetic dissection of human interferons
description	As revealed by population genetic analyses, different human interferon genes evolved under distinct selective constraints and signatures of positive selection vary according to geographic region, suggesting that some sequence changes may have conferred an advantage by increasing resistance to viral infection.
publisher	The Rockefeller University Press
publishDate	2011
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3244034/
_version_	1611496021548859392

Evolutionary genetic dissection of human interferons

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