A resource of vectors and ES cells for targeted deletion of microRNAs in mice

The 21-23 nucleotide single-stranded RNAs classified as microRNAs (miRNA) perform fundamental roles in a wide range of cellular and developmental processes. miRNAs regulate protein expression through sequence-specific base pairing with target messenger RNAs (mRNA) reducing both their stability and t...

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Bibliographic Details
Main Authors: Prosser, Haydn M., Koike-Yusa, Hiroko, Cooper, James D., Law, Frances C., Bradley, Allan
Format: Online
Language:English
Published: 2011
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3242032/