Subversion of membrane transport pathways by vacuolar pathogens
Mammalian phagocytes control bacterial infections effectively through phagocytosis, the process by which particles engulfed at the cell surface are transported to lysosomes for destruction. However, intracellular pathogens have evolved mechanisms to avoid this fate. Many bacterial pathogens use spec...
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| Format: | Online |
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The Rockefeller University Press
2011
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3241728/ |
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pubmed-32417282012-06-12 Subversion of membrane transport pathways by vacuolar pathogens Alix, Eric Mukherjee, Shaeri Roy, Craig R. Reviews Mammalian phagocytes control bacterial infections effectively through phagocytosis, the process by which particles engulfed at the cell surface are transported to lysosomes for destruction. However, intracellular pathogens have evolved mechanisms to avoid this fate. Many bacterial pathogens use specialized secretion systems to deliver proteins into host cells that subvert signaling pathways controlling membrane transport. These bacterial effectors modulate the function of proteins that regulate membrane transport and alter the phospholipid content of membranes. Elucidating the biochemical function of these effectors has provided a greater understanding of how bacteria control membrane transport to create a replicative niche within the host and provided insight into the regulation of membrane transport in eukaryotic cells. The Rockefeller University Press 2011-12-12 /pmc/articles/PMC3241728/ /pubmed/22123831 http://dx.doi.org/10.1083/jcb.201105019 Text en © 2011 Alix et al. This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 3.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/3.0/). |
| repository_type |
Open Access Journal |
| institution_category |
Foreign Institution |
| institution |
US National Center for Biotechnology Information |
| building |
NCBI PubMed |
| collection |
Online Access |
| language |
English |
| format |
Online |
| author |
Alix, Eric Mukherjee, Shaeri Roy, Craig R. |
| spellingShingle |
Alix, Eric Mukherjee, Shaeri Roy, Craig R. Subversion of membrane transport pathways by vacuolar pathogens |
| author_facet |
Alix, Eric Mukherjee, Shaeri Roy, Craig R. |
| author_sort |
Alix, Eric |
| title |
Subversion of membrane transport pathways by vacuolar pathogens |
| title_short |
Subversion of membrane transport pathways by vacuolar pathogens |
| title_full |
Subversion of membrane transport pathways by vacuolar pathogens |
| title_fullStr |
Subversion of membrane transport pathways by vacuolar pathogens |
| title_full_unstemmed |
Subversion of membrane transport pathways by vacuolar pathogens |
| title_sort |
subversion of membrane transport pathways by vacuolar pathogens |
| description |
Mammalian phagocytes control bacterial infections effectively through phagocytosis, the process by which particles engulfed at the cell surface are transported to lysosomes for destruction. However, intracellular pathogens have evolved mechanisms to avoid this fate. Many bacterial pathogens use specialized secretion systems to deliver proteins into host cells that subvert signaling pathways controlling membrane transport. These bacterial effectors modulate the function of proteins that regulate membrane transport and alter the phospholipid content of membranes. Elucidating the biochemical function of these effectors has provided a greater understanding of how bacteria control membrane transport to create a replicative niche within the host and provided insight into the regulation of membrane transport in eukaryotic cells. |
| publisher |
The Rockefeller University Press |
| publishDate |
2011 |
| url |
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3241728/ |
| _version_ |
1611495631443984384 |