Plexin B1 is repressed by oncogenic B-Raf signaling and functions as a tumor suppressor in melanoma cells

Plexin B1 is repressed by oncogenic B-Raf signaling and functions as a tumor suppressor in melanoma cells

Human melanomas show oncogenic B-Raf mutations which activate the B-Raf/MKK/ERK cascade. We screened microarrays to identify cellular targets of this pathway, and found that genes upregulated by B-Raf/MKK/ERK showed highest association with cell cycle regulators, whereas genes downregulated were mos...

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Bibliographic Details
Main Authors: Argast, Gretchen M., Croy, Carrie H., Couts, Kasey L., Zhang, Zhiyong, Litman, Elizabeth, Chan, Daniel C., Ahn, Natalie G.
Format: Online
Language:English
Published: 2009
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3238492/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3238492/

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