Phosphatidylinositol 4,5-bisphosphate (PIP2) controls magnesium gatekeeper TRPM6 activity

Phosphatidylinositol 4,5-bisphosphate (PIP2) controls magnesium gatekeeper TRPM6 activity

TRPM6 is crucial for human Mg2+ homeostasis as patients carrying TRPM6 mutations develop hypomagnesemia and secondary hypocalcemia (HSH). However, the activation mechanism of TRPM6 has remained unknown. Here we demonstrate that phosphatidylinositol-4,5-bisphophate (PIP2) controls TRPM6 activation an...

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Bibliographic Details
Main Authors: Xie, Jia, Sun, Baonan, Du, Jianyang, Yang, Wenzhong, Chen, Hsiang-Chin, Overton, Jeffrey D., Runnels, Loren W., Yue, Lixia
Format: Online
Language:English
Published: Nature Publishing Group 2011
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3238349/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3238349/

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