A Novel Cardioprotective Agent in Cardiac Transplantation: Metformin Activation of AMP-Activated Protein Kinase Decreases Acute Ischemia-Reperfusion Injury and Chronic Rejection

A Novel Cardioprotective Agent in Cardiac Transplantation: Metformin Activation of AMP-Activated Protein Kinase Decreases Acute Ischemia-Reperfusion Injury and Chronic Rejection

The main cause of mortality after the first year from cardiac transplantation is cardiac allograft vasculopathy (CAV), which leads to chronic rejection of the heart. To improve long-term outcomes in cardiac transplantation, treatments to prevent or diminish CAV are actively being researched. Ischemi...

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Bibliographic Details
Main Authors: Chin, Jocelyn T., Troke, Joshua J., Kimura, Naoyuki, Itoh, Satoshi, Wang, Xi, Palmer, Owen P., Robbins, Robert C., Fischbein, Michael P.
Format: Online
Language:English
Published: YJBM 2011
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3238328/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3238328/

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