The Cx26-G45E mutation displays increased hemichannel activity in a mouse model of the lethal form of keratitis-ichthyosis-deafness syndrome

The Cx26-G45E mutation displays increased hemichannel activity in a mouse model of the lethal form of keratitis-ichthyosis-deafness syndrome

Dominant Cx26 mutations that cause keratitis-ichthyosis-deafness syndrome (KIDS) show increased hemichannel activity. Transgenic expression of these mutations recapitulates human skin disease in mice. Excess hemichannel activity persists in diseased epidermis from the transgenic mice. Thus hemichann...

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Bibliographic Details
Main Authors: Mese, Gulistan, Sellitto, Caterina, Li, Leping, Wang, Hong-Zhan, Valiunas, Virginijus, Richard, Gabriele, Brink, Peter R., White, Thomas W.
Format: Online
Language:English
Published: The American Society for Cell Biology 2011
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3237621/

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3237621/

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