Pilot data on telmisartan short-term effects on glucose metabolism in the olfactory tract in Alzheimer's disease

The possible effect of antihypertensive therapy on Alzheimer's disease (AD) has been studied, and angiotensin II receptor blockers (ARBs) have been suggested to exert an effect on cognitive decline. The purpose of this study is to clarify the functional effects of telmisartan, a long-acting ARB...

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Main Authors:	Imabayashi, Etsuko, Matsuda, Hiroshi, Yoshimaru, Kimiko, Kuji, Ichiei, Seto, Akira, Shimano, Yasumasa, Ito, Kimiteru, Kikuta, Daisuke, Shimazu, Tomokazu, Araki, Nobuo
Format:	Online
Language:	English
Published:	Blackwell Publishing Inc 2011
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3236542/

id	pubmed-3236542
recordtype	oai_dc
spelling	pubmed-32365422011-12-23 Pilot data on telmisartan short-term effects on glucose metabolism in the olfactory tract in Alzheimer's disease Imabayashi, Etsuko Matsuda, Hiroshi Yoshimaru, Kimiko Kuji, Ichiei Seto, Akira Shimano, Yasumasa Ito, Kimiteru Kikuta, Daisuke Shimazu, Tomokazu Araki, Nobuo Original Research The possible effect of antihypertensive therapy on Alzheimer's disease (AD) has been studied, and angiotensin II receptor blockers (ARBs) have been suggested to exert an effect on cognitive decline. The purpose of this study is to clarify the functional effects of telmisartan, a long-acting ARB, on AD brain using prospective longitudinal 18F-fluorodeoxyglucose positron emission tomography (FDG-PET) studies. For this purpose, brain glucose metabolism of four hypertensive patients with AD was examined with FDG-PET before and after administration of telmisartan. Studied subjects underwent three FDG-PET studies at intervals of 12 weeks. Antihypertensive treatment except for telmisartan was started after the first FDG-PET and continued for 24 weeks. Then 40–80 mg of telmisartan was added after the second FDG-PET and continued for 12 weeks.Glucose metabolism was significantly decreased during the first 12 weeks without telmisartan use at an area (−10, 21, −22, x, y, z; Z = 3.56) caudal to the left rectal gyrus and the olfactory sulcus corresponding to the left olfactory tract. In contrast, the introduction of telmisartan during the following 12 weeks preserved glucose metabolism at areas (5, 19, −20, x, y, z; Z = 3.09; 6, 19, −22, x, y, z; Z = 2.88) caudal to the bilateral rectal gyri and olfactory sulci corresponding to the bilateral olfactory tracts. No areas showed decreased glucose metabolism after the introduction of telmisartan. In AD, amyloid-β deposition is observed in the anterior olfactory nucleus (AON) of the olfactory tract. Glucose metabolism in AON may be progressively decreased and preserved by telmisartan. Blackwell Publishing Inc 2011-11 /pmc/articles/PMC3236542/ /pubmed/22399085 http://dx.doi.org/10.1002/brb3.13 Text en © 2011 The Authors. Published by Wiley Periodicals, Inc.
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Imabayashi, Etsuko Matsuda, Hiroshi Yoshimaru, Kimiko Kuji, Ichiei Seto, Akira Shimano, Yasumasa Ito, Kimiteru Kikuta, Daisuke Shimazu, Tomokazu Araki, Nobuo
spellingShingle	Imabayashi, Etsuko Matsuda, Hiroshi Yoshimaru, Kimiko Kuji, Ichiei Seto, Akira Shimano, Yasumasa Ito, Kimiteru Kikuta, Daisuke Shimazu, Tomokazu Araki, Nobuo Pilot data on telmisartan short-term effects on glucose metabolism in the olfactory tract in Alzheimer's disease
author_facet	Imabayashi, Etsuko Matsuda, Hiroshi Yoshimaru, Kimiko Kuji, Ichiei Seto, Akira Shimano, Yasumasa Ito, Kimiteru Kikuta, Daisuke Shimazu, Tomokazu Araki, Nobuo
author_sort	Imabayashi, Etsuko
title	Pilot data on telmisartan short-term effects on glucose metabolism in the olfactory tract in Alzheimer's disease
title_short	Pilot data on telmisartan short-term effects on glucose metabolism in the olfactory tract in Alzheimer's disease
title_full	Pilot data on telmisartan short-term effects on glucose metabolism in the olfactory tract in Alzheimer's disease
title_fullStr	Pilot data on telmisartan short-term effects on glucose metabolism in the olfactory tract in Alzheimer's disease
title_full_unstemmed	Pilot data on telmisartan short-term effects on glucose metabolism in the olfactory tract in Alzheimer's disease
title_sort	pilot data on telmisartan short-term effects on glucose metabolism in the olfactory tract in alzheimer's disease
description	The possible effect of antihypertensive therapy on Alzheimer's disease (AD) has been studied, and angiotensin II receptor blockers (ARBs) have been suggested to exert an effect on cognitive decline. The purpose of this study is to clarify the functional effects of telmisartan, a long-acting ARB, on AD brain using prospective longitudinal 18F-fluorodeoxyglucose positron emission tomography (FDG-PET) studies. For this purpose, brain glucose metabolism of four hypertensive patients with AD was examined with FDG-PET before and after administration of telmisartan. Studied subjects underwent three FDG-PET studies at intervals of 12 weeks. Antihypertensive treatment except for telmisartan was started after the first FDG-PET and continued for 24 weeks. Then 40–80 mg of telmisartan was added after the second FDG-PET and continued for 12 weeks.Glucose metabolism was significantly decreased during the first 12 weeks without telmisartan use at an area (−10, 21, −22, x, y, z; Z = 3.56) caudal to the left rectal gyrus and the olfactory sulcus corresponding to the left olfactory tract. In contrast, the introduction of telmisartan during the following 12 weeks preserved glucose metabolism at areas (5, 19, −20, x, y, z; Z = 3.09; 6, 19, −22, x, y, z; Z = 2.88) caudal to the bilateral rectal gyri and olfactory sulci corresponding to the bilateral olfactory tracts. No areas showed decreased glucose metabolism after the introduction of telmisartan. In AD, amyloid-β deposition is observed in the anterior olfactory nucleus (AON) of the olfactory tract. Glucose metabolism in AON may be progressively decreased and preserved by telmisartan.
publisher	Blackwell Publishing Inc
publishDate	2011
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3236542/
_version_	1611493571955785728

Pilot data on telmisartan short-term effects on glucose metabolism in the olfactory tract in Alzheimer's disease

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