Epigenetic repression of the Igk locus by STAT5-mediated Ezh2 recruitment

Epigenetic repression of the Igk locus by STAT5-mediated Ezh2 recruitment

During B lymphopoiesis, Igk recombination requires pre-B cell receptor (pre-BCR) expression and escape from interleukin 7 receptor (IL-7R) signaling. By activating the transcription factor STAT5, IL-7R signaling maintains proliferation and represses Igk germline transcription by unknown mechanisms....

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Bibliographic Details
Main Authors: Mandal, Malay, Powers, Sarah E., Maienschein-Cline, Mark, Bartom, Elizabeth T., Hamel, Keith M., Kee, Barbara L., Dinner, Aaron R., Clark, Marcus R.
Format: Online
Language:English
Published: 2011
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3233979/

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3233979/

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