In Silico Identification of Structure Requirement for Novel Thiazole and Oxazole Derivatives as Potent Fructose 1,6-Bisphosphatase Inhibitors

In Silico Identification of Structure Requirement for Novel Thiazole and Oxazole Derivatives as Potent Fructose 1,6-Bisphosphatase Inhibitors

Fructose 1,6-bisphosphatase (FBPase) has been identified as a drug discovery target for lowering glucose in type 2 diabetes mellitus. In this study, a large series of 105 FBPase inhibitors were studied using a combinational method by 3D-QSAR, molecular docking and molecular dynamics simulations for...

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Bibliographic Details
Main Authors: Hao, Ming, Zhang, Xiaole, Ren, Hong, Li, Yan, Zhang, Shuwei, Luo, Fang, Ji, Mingjuan, Li, Guohui, Yang, Ling
Format: Online
Language:English
Published: Molecular Diversity Preservation International (MDPI) 2011
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3233463/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3233463/

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