Mannose Receptor (MR) Engagement by Mesothelin GPI Anchor Polarizes Tumor-Associated Macrophages and Is Blocked by Anti-MR Human Recombinant Antibody

Mannose Receptor (MR) Engagement by Mesothelin GPI Anchor Polarizes Tumor-Associated Macrophages and Is Blocked by Anti-MR Human Recombinant Antibody

Tumor-infiltrating macrophages respond to microenvironmental signals by developing a tumor-associated phenotype characterized by high expression of mannose receptor (MR, CD206). Antibody cross-linking of CD206 triggers anergy in dendritic cells and CD206 engagement by tumoral mucins activates an imm...

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Bibliographic Details
Main Authors: Dangaj, Denarda, Abbott, Karen L., Mookerjee, Ananda, Zhao, Aizhi, Kirby, Pamela S., Sandaltzopoulos, Raphael, Powell, Daniel J., Lamazière, Antonin, Siegel, Don L., Wolf, Claude, Scholler, Nathalie
Format: Online
Language:English
Published: Public Library of Science 2011
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3232216/

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3232216/

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