Small molecule inhibitors reveal Niemann-Pick C1 is essential for ebolavirus infection

Ebolavirus (EboV) is a highly pathogenic enveloped virus that causes outbreaks of zoonotic infection in Africa. The clinical symptoms are manifestations of the massive production of pro-inflammatory cytokines in response to infection1 and in many outbreaks, mortality exceeds 75%. The unpredictable o...

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Bibliographic Details
Main Authors: Côté, Marceline, Misasi, John, Ren, Tao, Bruchez, Anna, Lee, Kyungae, Filone, Claire Marie, Hensley, Lisa, Li, Qi, Ory, Daniel, Chandran, Kartik, Cunningham, James
Format: Online
Language:English
Published: 2011
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3230319/