Integrating Genome-Wide Genetic Variations and Monocyte Expression Data Reveals Trans-Regulated Gene Modules in Humans

Integrating Genome-Wide Genetic Variations and Monocyte Expression Data Reveals Trans-Regulated Gene Modules in Humans

One major expectation from the transcriptome in humans is to characterize the biological basis of associations identified by genome-wide association studies. So far, few cis expression quantitative trait loci (eQTLs) have been reliably related to disease susceptibility. Trans-regulating mechanisms m...

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Main Authors: Rotival, Maxime, Zeller, Tanja, Wild, Philipp S., Maouche, Seraya, Szymczak, Silke, Schillert, Arne, Castagné, Raphaele, Deiseroth, Arne, Proust, Carole, Brocheton, Jessy, Godefroy, Tiphaine, Perret, Claire, Germain, Marine, Eleftheriadis, Medea, Sinning, Christoph R., Schnabel, Renate B., Lubos, Edith, Lackner, Karl J., Rossmann, Heidi, Münzel, Thomas, Rendon, Augusto, Consortium, Cardiogenics, Erdmann, Jeanette, Deloukas, Panos, Hengstenberg, Christian, Diemert, Patrick, Montalescot, Gilles, Ouwehand, Willem H., Samani, Nilesh J., Schunkert, Heribert, Tregouet, David-Alexandre, Ziegler, Andreas, Goodall, Alison H., Cambien, François, Tiret, Laurence, Blankenberg, Stefan
Format: Online
Language:English
Published: Public Library of Science 2011
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3228821/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3228821/

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