β-Catenin and Smad3 regulate the activity and stability of myocardin-related transcription factor during epithelial–myofibroblast transition

β-Catenin and Smad3 regulate the activity and stability of myocardin-related transcription factor during epithelial–myofibroblast transition

Two novel mechanisms are shown by which injury of intercellular junctions via β-catenin promotes epithelial–myofibroblast transition. β-Catenin interacts with Smad3, thereby preventing the inhibitory effect of the latter on myocardin-related transcription factor (MRTF), and maintains MRTF stability...

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Main Authors: Charbonney, Emmanuel, Speight, Pam, Masszi, András, Nakano, Hiroyasu, Kapus, András
Format: Online
Language:English
Published: The American Society for Cell Biology 2011
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3226468/
id pubmed-3226468
recordtype oai_dc
spelling pubmed-32264682012-02-16 β-Catenin and Smad3 regulate the activity and stability of myocardin-related transcription factor during epithelial–myofibroblast transition Charbonney, Emmanuel Speight, Pam Masszi, András Nakano, Hiroyasu Kapus, András Articles Two novel mechanisms are shown by which injury of intercellular junctions via β-catenin promotes epithelial–myofibroblast transition. β-Catenin interacts with Smad3, thereby preventing the inhibitory effect of the latter on myocardin-related transcription factor (MRTF), and maintains MRTF stability by inhibiting Smad3-mediated, GSK-3β–dependent degradation of MRTF. The American Society for Cell Biology 2011-12-01 /pmc/articles/PMC3226468/ /pubmed/21965288 http://dx.doi.org/10.1091/mbc.E11-04-0335 Text en © 2011 Charbonney et al. This article is distributed by The American Society for Cell Biology under license from the author(s). Two months after publication it is available to the public under an Attribution–Noncommercial–Share Alike 3.0 Unported Creative Commons License (http://creativecommons.org/licenses/by-nc-sa/3.0). “ASCB®,” “The American Society for Cell Biology®,” and “Molecular Biology of the Cell®” are registered trademarks of The American Society of Cell Biology.
repository_type Open Access Journal
institution_category Foreign Institution
institution US National Center for Biotechnology Information
building NCBI PubMed
collection Online Access
language English
format Online
author Charbonney, Emmanuel
Speight, Pam
Masszi, András
Nakano, Hiroyasu
Kapus, András
spellingShingle Charbonney, Emmanuel
Speight, Pam
Masszi, András
Nakano, Hiroyasu
Kapus, András
β-Catenin and Smad3 regulate the activity and stability of myocardin-related transcription factor during epithelial–myofibroblast transition
author_facet Charbonney, Emmanuel
Speight, Pam
Masszi, András
Nakano, Hiroyasu
Kapus, András
author_sort Charbonney, Emmanuel
title β-Catenin and Smad3 regulate the activity and stability of myocardin-related transcription factor during epithelial–myofibroblast transition
title_short β-Catenin and Smad3 regulate the activity and stability of myocardin-related transcription factor during epithelial–myofibroblast transition
title_full β-Catenin and Smad3 regulate the activity and stability of myocardin-related transcription factor during epithelial–myofibroblast transition
title_fullStr β-Catenin and Smad3 regulate the activity and stability of myocardin-related transcription factor during epithelial–myofibroblast transition
title_full_unstemmed β-Catenin and Smad3 regulate the activity and stability of myocardin-related transcription factor during epithelial–myofibroblast transition
title_sort β-catenin and smad3 regulate the activity and stability of myocardin-related transcription factor during epithelial–myofibroblast transition
description Two novel mechanisms are shown by which injury of intercellular junctions via β-catenin promotes epithelial–myofibroblast transition. β-Catenin interacts with Smad3, thereby preventing the inhibitory effect of the latter on myocardin-related transcription factor (MRTF), and maintains MRTF stability by inhibiting Smad3-mediated, GSK-3β–dependent degradation of MRTF.
publisher The American Society for Cell Biology
publishDate 2011
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3226468/
_version_ 1611490675556089856

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