Molecular Targets for the Treatment of Juvenile Myelomonocytic Leukemia
Significant advances in our understanding of the genetic defects and the pathogenesis of juvenile myelomonocytic leukemia (JMML) have been achieved in the last several years. The information gathered tremendously helps us in designing molecular targeted therapies for this otherwise fatal disease. Va...
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| Format: | Online |
| Language: | English |
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Hindawi Publishing Corporation
2012
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3226315/ |
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pubmed-3226315 |
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pubmed-32263152011-12-08 Molecular Targets for the Treatment of Juvenile Myelomonocytic Leukemia Liu, Xiaoling Sabnis, Himalee Bunting, Kevin D. Qu, Cheng-Kui Review Article Significant advances in our understanding of the genetic defects and the pathogenesis of juvenile myelomonocytic leukemia (JMML) have been achieved in the last several years. The information gathered tremendously helps us in designing molecular targeted therapies for this otherwise fatal disease. Various approaches are being investigated to target defective pathways/molecules in this disease. However, effective therapy is still lacking. Development of specific target-based drugs for JMML remains a big challenge and represents a promising direction in this field. Hindawi Publishing Corporation 2012 2011-11-13 /pmc/articles/PMC3226315/ /pubmed/22162691 http://dx.doi.org/10.1155/2012/308252 Text en Copyright © 2012 Xiaoling Liu et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
| repository_type |
Open Access Journal |
| institution_category |
Foreign Institution |
| institution |
US National Center for Biotechnology Information |
| building |
NCBI PubMed |
| collection |
Online Access |
| language |
English |
| format |
Online |
| author |
Liu, Xiaoling Sabnis, Himalee Bunting, Kevin D. Qu, Cheng-Kui |
| spellingShingle |
Liu, Xiaoling Sabnis, Himalee Bunting, Kevin D. Qu, Cheng-Kui Molecular Targets for the Treatment of Juvenile Myelomonocytic Leukemia |
| author_facet |
Liu, Xiaoling Sabnis, Himalee Bunting, Kevin D. Qu, Cheng-Kui |
| author_sort |
Liu, Xiaoling |
| title |
Molecular Targets for the Treatment of Juvenile Myelomonocytic Leukemia |
| title_short |
Molecular Targets for the Treatment of Juvenile Myelomonocytic Leukemia |
| title_full |
Molecular Targets for the Treatment of Juvenile Myelomonocytic Leukemia |
| title_fullStr |
Molecular Targets for the Treatment of Juvenile Myelomonocytic Leukemia |
| title_full_unstemmed |
Molecular Targets for the Treatment of Juvenile Myelomonocytic Leukemia |
| title_sort |
molecular targets for the treatment of juvenile myelomonocytic leukemia |
| description |
Significant advances in our understanding of the genetic defects and the pathogenesis of juvenile myelomonocytic leukemia (JMML) have been achieved in the last several years. The information gathered tremendously helps us in designing molecular targeted therapies for this otherwise fatal disease. Various approaches are being investigated to target defective pathways/molecules in this disease. However, effective therapy is still lacking. Development of specific target-based drugs for JMML remains a big challenge and represents a promising direction in this field. |
| publisher |
Hindawi Publishing Corporation |
| publishDate |
2012 |
| url |
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3226315/ |
| _version_ |
1611490626650505216 |