Xanthine Oxidase-Derived ROS Upregulate Egr-1 via ERK1/2 in PA Smooth Muscle Cells; Model to Test Impact of Extracellular ROS in Chronic Hypoxia

Xanthine Oxidase-Derived ROS Upregulate Egr-1 via ERK1/2 in PA Smooth Muscle Cells; Model to Test Impact of Extracellular ROS in Chronic Hypoxia

Exposure of newborn calves to chronic hypoxia causes pulmonary artery (PA) hypertension and remodeling. Previous studies showed that the redox-sensitive transcription factor, early growth response-1 (Egr-1), is upregulated in the PA of chronically hypoxic calves and regulates cell proliferation. Fur...

Full description

Bibliographic Details
Main Authors: Hartney, Tanya, Birari, Rahul, Venkataraman, Sujatha, Villegas, Leah, Martinez, Maylyn, Black, Stephen M., Stenmark, Kurt R., Nozik-Grayck, Eva
Format: Online
Language:English
Published: Public Library of Science 2011
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3225357/

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3225357/

Similar Items