Emerging Roles of Glycogen Synthase Kinase 3 in the Treatment of Brain Tumors
The constitutively active protein glycogen synthase kinase 3 (GSK3), a serine/threonine kinase, acts paradoxically as a tumor suppressor in some cancers while potentiates growth in others. Deciphering what governs its actions is vital for understanding many pathological conditions, including brain c...
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| Format: | Online |
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Frontiers Research Foundation
2011
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3223722/ |
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pubmed-32237222012-01-24 Emerging Roles of Glycogen Synthase Kinase 3 in the Treatment of Brain Tumors Mills, Caroline N. Nowsheen, Somaira Bonner, James A. Yang, Eddy S. Neuroscience The constitutively active protein glycogen synthase kinase 3 (GSK3), a serine/threonine kinase, acts paradoxically as a tumor suppressor in some cancers while potentiates growth in others. Deciphering what governs its actions is vital for understanding many pathological conditions, including brain cancer. What are seemingly disparate roles of GSK3 stems from the complex regulation of many cellular functions by GSK3. This review focuses on the regulation of GSK3, its role in survival, apoptosis and DNA damage, and finally its potential therapeutic impact in brain cancer. A thorough understanding of this versatile protein is critical for improving the outcome of various diseases, especially cancer. Frontiers Research Foundation 2011-11-25 /pmc/articles/PMC3223722/ /pubmed/22275880 http://dx.doi.org/10.3389/fnmol.2011.00047 Text en Copyright © 2011 Mills, Nowsheen, Bonner and Yang. http://www.frontiersin.org/licenseagreement This is an open-access article subject to a non-exclusive license between the authors and Frontiers Media SA, which permits use, distribution and reproduction in other forums, provided the original authors and source are credited and other Frontiers conditions are complied with. |
| repository_type |
Open Access Journal |
| institution_category |
Foreign Institution |
| institution |
US National Center for Biotechnology Information |
| building |
NCBI PubMed |
| collection |
Online Access |
| language |
English |
| format |
Online |
| author |
Mills, Caroline N. Nowsheen, Somaira Bonner, James A. Yang, Eddy S. |
| spellingShingle |
Mills, Caroline N. Nowsheen, Somaira Bonner, James A. Yang, Eddy S. Emerging Roles of Glycogen Synthase Kinase 3 in the Treatment of Brain Tumors |
| author_facet |
Mills, Caroline N. Nowsheen, Somaira Bonner, James A. Yang, Eddy S. |
| author_sort |
Mills, Caroline N. |
| title |
Emerging Roles of Glycogen Synthase Kinase 3 in the Treatment of Brain Tumors |
| title_short |
Emerging Roles of Glycogen Synthase Kinase 3 in the Treatment of Brain Tumors |
| title_full |
Emerging Roles of Glycogen Synthase Kinase 3 in the Treatment of Brain Tumors |
| title_fullStr |
Emerging Roles of Glycogen Synthase Kinase 3 in the Treatment of Brain Tumors |
| title_full_unstemmed |
Emerging Roles of Glycogen Synthase Kinase 3 in the Treatment of Brain Tumors |
| title_sort |
emerging roles of glycogen synthase kinase 3 in the treatment of brain tumors |
| description |
The constitutively active protein glycogen synthase kinase 3 (GSK3), a serine/threonine kinase, acts paradoxically as a tumor suppressor in some cancers while potentiates growth in others. Deciphering what governs its actions is vital for understanding many pathological conditions, including brain cancer. What are seemingly disparate roles of GSK3 stems from the complex regulation of many cellular functions by GSK3. This review focuses on the regulation of GSK3, its role in survival, apoptosis and DNA damage, and finally its potential therapeutic impact in brain cancer. A thorough understanding of this versatile protein is critical for improving the outcome of various diseases, especially cancer. |
| publisher |
Frontiers Research Foundation |
| publishDate |
2011 |
| url |
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3223722/ |
| _version_ |
1611489885208707072 |