Musashi expression in β-cells coordinates insulin expression, apoptosis and proliferation in response to endoplasmic reticulum stress in diabetes

Musashi expression in β-cells coordinates insulin expression, apoptosis and proliferation in response to endoplasmic reticulum stress in diabetes

Diabetes is associated with the death and dysfunction of insulin-producing pancreatic β-cells. In other systems, Musashi genes regulate cell fate via Notch signaling, which we recently showed regulates β-cell survival. Here we show for the first time that human and mouse adult islet cells express mR...

Full description

Bibliographic Details
Main Authors: Szabat, M, Kalynyak, T B, Lim, G E, Chu, K Y, Yang, Y H, Asadi, A, Gage, B K, Ao, Z, Warnock, G L, Piret, J M, Kieffer, T J, Johnson, J D
Format: Online
Language:English
Published: Nature Publishing Group 2011
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3223700/

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3223700/

Similar Items