Reduced Coupling of Oxidative Phosphorylation In Vivo Precedes Electron Transport Chain Defects Due to Mild Oxidative Stress in Mice

Reduced Coupling of Oxidative Phosphorylation In Vivo Precedes Electron Transport Chain Defects Due to Mild Oxidative Stress in Mice

Oxidative stress and mitochondrial function are at the core of many degenerative conditions. However, the interaction between oxidative stress and in vivo mitochondrial function is unclear. We used both pharmacological (2 week paraquat (PQ) treatment of wild type mice) and transgenic (mice lacking C...

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Bibliographic Details
Main Authors: Siegel, Michael P., Kruse, Shane E., Knowels, Gary, Salmon, Adam, Beyer, Richard, Xie, Hui, Van Remmen, Holly, Smith, Steven R., Marcinek, David J.
Format: Online
Language:English
Published: Public Library of Science 2011
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3222658/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3222658/

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