Dural MALT lymphoma with disseminated disease

Central nervous system (CNS) lymphoma involving the dura mater is very rare and histologically is usually a subtype of non-Hodgkin's lymphoma (NHL) termed mucosa-associated lymphoid tissue (MALT) lymphoma. We present a case of a 46-year old woman with dural MALT lymphoma that was found to also...

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Main Authors:	Matmati, Kelly, Matmati, Nabil, Hannun, Yusuf A., Rumboldt, Zoran, Patel, Sunil, Lazarchick, John, Stuart, Robert, Giglio, Pierre
Format:	Online
Language:	English
Published:	PAGEPress Publications 2010
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3222263/

id	pubmed-3222263
recordtype	oai_dc
spelling	pubmed-32222632011-12-19 Dural MALT lymphoma with disseminated disease Matmati, Kelly Matmati, Nabil Hannun, Yusuf A. Rumboldt, Zoran Patel, Sunil Lazarchick, John Stuart, Robert Giglio, Pierre Case Report Central nervous system (CNS) lymphoma involving the dura mater is very rare and histologically is usually a subtype of non-Hodgkin's lymphoma (NHL) termed mucosa-associated lymphoid tissue (MALT) lymphoma. We present a case of a 46-year old woman with dural MALT lymphoma that was found to also involve a lacrimal gland, inguinal lymph nodes, and bone marrow. Magnetic resonance imaging of the brain showed an extra-axial enhancing mass approximately 6 cm in maximum diameter along the right frontotemporal convexity. Histopathology of the resected dural mass showed MALT lymphoma expressing CD20, CD52, CD19, and CD38. Molecular studies of the B-cell receptor heavy chain demonstrated monoclonality at the involved sites. The patient was treated with four cycles of fludarabine, mitoxantrone, and rituximab with complete remission. She had recurrence in the subcutaneous tissue of the back at 12 months but has remained free of intracranial disease for 31 months. A review of the literature reveals 57 cases of dural MALT lymphoma. Only 4 had extra-CNS involvement at presentation, and only 3 had local recurrence of the dural tumor. Because of the indolent behavior of this tumor, the intracranial portion can be treated conservatively after resection with or without chemotherapy. Deferral of brain radiation can be considered with close clinical and neuroimaging follow up. PAGEPress Publications 2010-12-03 /pmc/articles/PMC3222263/ /pubmed/22184513 http://dx.doi.org/10.4081/hr.2010.e10 Text en ©Copyright K. Matmati et al., 2010 This work is licensed under a Creative Commons Attribution 3.0 License (by-nc 3.0). Licensee PAGEPress, Italy
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Matmati, Kelly Matmati, Nabil Hannun, Yusuf A. Rumboldt, Zoran Patel, Sunil Lazarchick, John Stuart, Robert Giglio, Pierre
spellingShingle	Matmati, Kelly Matmati, Nabil Hannun, Yusuf A. Rumboldt, Zoran Patel, Sunil Lazarchick, John Stuart, Robert Giglio, Pierre Dural MALT lymphoma with disseminated disease
author_facet	Matmati, Kelly Matmati, Nabil Hannun, Yusuf A. Rumboldt, Zoran Patel, Sunil Lazarchick, John Stuart, Robert Giglio, Pierre
author_sort	Matmati, Kelly
title	Dural MALT lymphoma with disseminated disease
title_short	Dural MALT lymphoma with disseminated disease
title_full	Dural MALT lymphoma with disseminated disease
title_fullStr	Dural MALT lymphoma with disseminated disease
title_full_unstemmed	Dural MALT lymphoma with disseminated disease
title_sort	dural malt lymphoma with disseminated disease
description	Central nervous system (CNS) lymphoma involving the dura mater is very rare and histologically is usually a subtype of non-Hodgkin's lymphoma (NHL) termed mucosa-associated lymphoid tissue (MALT) lymphoma. We present a case of a 46-year old woman with dural MALT lymphoma that was found to also involve a lacrimal gland, inguinal lymph nodes, and bone marrow. Magnetic resonance imaging of the brain showed an extra-axial enhancing mass approximately 6 cm in maximum diameter along the right frontotemporal convexity. Histopathology of the resected dural mass showed MALT lymphoma expressing CD20, CD52, CD19, and CD38. Molecular studies of the B-cell receptor heavy chain demonstrated monoclonality at the involved sites. The patient was treated with four cycles of fludarabine, mitoxantrone, and rituximab with complete remission. She had recurrence in the subcutaneous tissue of the back at 12 months but has remained free of intracranial disease for 31 months. A review of the literature reveals 57 cases of dural MALT lymphoma. Only 4 had extra-CNS involvement at presentation, and only 3 had local recurrence of the dural tumor. Because of the indolent behavior of this tumor, the intracranial portion can be treated conservatively after resection with or without chemotherapy. Deferral of brain radiation can be considered with close clinical and neuroimaging follow up.
publisher	PAGEPress Publications
publishDate	2010
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3222263/
_version_	1611489573057069056

Dural MALT lymphoma with disseminated disease

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