Overexpression of Bcl2 in Osteoblasts Inhibits Osteoblast Differentiation and Induces Osteocyte Apoptosis

Overexpression of Bcl2 in Osteoblasts Inhibits Osteoblast Differentiation and Induces Osteocyte Apoptosis

Bcl2 subfamily proteins, including Bcl2 and Bcl-XL, inhibit apoptosis. As osteoblast apoptosis is in part responsible for osteoporosis in sex steroid deficiency, glucocorticoid excess, and aging, bone loss might be inhibited by the upregulation of Bcl2; however, the effects of Bcl2 overexpression on...

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Bibliographic Details
Main Authors: Moriishi, Takeshi, Maruyama, Zenjiro, Fukuyama, Ryo, Ito, Masako, Miyazaki, Toshihiro, Kitaura, Hideki, Ohnishi, Hidetake, Furuichi, Tatsuya, Kawai, Yosuke, Masuyama, Ritsuko, Komori, Hisato, Takada, Kenji, Kawaguchi, Hiroshi, Komori, Toshihisa
Format: Online
Language:English
Published: Public Library of Science 2011
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3219663/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3219663/

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