IL-17 in spondyloarthritis: is the T-party over?
The past decade has witnessed significant progress in revealing an important role for IL-17 in the pathogenesis of several immune-mediated inflammatory diseases. Recent studies have provided new insights into the cellular source of IL-17, originally identified as the signature cytokine of a distinct...
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| Format: | Online |
| Language: | English |
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BioMed Central
2011
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3218894/ |
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pubmed-3218894 |
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pubmed-32188942011-12-24 IL-17 in spondyloarthritis: is the T-party over? Yeremenko, Nataliya Baeten, Dominique Editorial The past decade has witnessed significant progress in revealing an important role for IL-17 in the pathogenesis of several immune-mediated inflammatory diseases. Recent studies have provided new insights into the cellular source of IL-17, originally identified as the signature cytokine of a distinct CD4+ T-cell subset known as Th17. Accumulating evidence suggests that the majority of the IL-17 released in inflammatory arthritis is produced by innate immune cells rather than T cells. Understanding molecular mechanisms behind these early innate immune responses will be the key to designing rational therapies targeting these important inflammatory pathways. BioMed Central 2011 2011-06-24 /pmc/articles/PMC3218894/ /pubmed/21722352 http://dx.doi.org/10.1186/ar3351 Text en Copyright ©2011 BioMed Central Ltd |
| repository_type |
Open Access Journal |
| institution_category |
Foreign Institution |
| institution |
US National Center for Biotechnology Information |
| building |
NCBI PubMed |
| collection |
Online Access |
| language |
English |
| format |
Online |
| author |
Yeremenko, Nataliya Baeten, Dominique |
| spellingShingle |
Yeremenko, Nataliya Baeten, Dominique IL-17 in spondyloarthritis: is the T-party over? |
| author_facet |
Yeremenko, Nataliya Baeten, Dominique |
| author_sort |
Yeremenko, Nataliya |
| title |
IL-17 in spondyloarthritis: is the T-party over? |
| title_short |
IL-17 in spondyloarthritis: is the T-party over? |
| title_full |
IL-17 in spondyloarthritis: is the T-party over? |
| title_fullStr |
IL-17 in spondyloarthritis: is the T-party over? |
| title_full_unstemmed |
IL-17 in spondyloarthritis: is the T-party over? |
| title_sort |
il-17 in spondyloarthritis: is the t-party over? |
| description |
The past decade has witnessed significant progress in revealing an important role for IL-17 in the pathogenesis of several immune-mediated inflammatory diseases. Recent studies have provided new insights into the cellular source of IL-17, originally identified as the signature cytokine of a distinct CD4+ T-cell subset known as Th17. Accumulating evidence suggests that the majority of the IL-17 released in inflammatory arthritis is produced by innate immune cells rather than T cells. Understanding molecular mechanisms behind these early innate immune responses will be the key to designing rational therapies targeting these important inflammatory pathways. |
| publisher |
BioMed Central |
| publishDate |
2011 |
| url |
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3218894/ |
| _version_ |
1611488435663536128 |