MicroRNA biogenesis and regulation of bone remodeling

MicroRNAs (miRNAs) are key post-transcriptional regulators of gene expression. This review will highlight our current understanding of miRNA biogenesis and mechanisms of action, and will summarize recent work on the role of miRNAs, including the miR-29 family, in bone remodeling. These studies repre...

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Bibliographic Details
Main Authors:	Kapinas, Kristina, Delany, Anne M
Format:	Online
Language:	English
Published:	BioMed Central 2011
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3218876/

id	pubmed-3218876
recordtype	oai_dc
spelling	pubmed-32188762011-11-27 MicroRNA biogenesis and regulation of bone remodeling Kapinas, Kristina Delany, Anne M Review MicroRNAs (miRNAs) are key post-transcriptional regulators of gene expression. This review will highlight our current understanding of miRNA biogenesis and mechanisms of action, and will summarize recent work on the role of miRNAs, including the miR-29 family, in bone remodeling. These studies represent the first steps in demonstrating the importance of miRNAs in the control of osteoblast and osteoclast differentiation and function. An in-depth understanding of the roles of these regulatory RNAs in the skeleton will be critical for the development of new therapeutics aimed at treating bone loss and perhaps facilitating fracture repair. BioMed Central 2011 2011-05-27 /pmc/articles/PMC3218876/ /pubmed/21635717 http://dx.doi.org/10.1186/ar3325 Text en Copyright ©2011 BioMed Central Ltd
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Kapinas, Kristina Delany, Anne M
spellingShingle	Kapinas, Kristina Delany, Anne M MicroRNA biogenesis and regulation of bone remodeling
author_facet	Kapinas, Kristina Delany, Anne M
author_sort	Kapinas, Kristina
title	MicroRNA biogenesis and regulation of bone remodeling
title_short	MicroRNA biogenesis and regulation of bone remodeling
title_full	MicroRNA biogenesis and regulation of bone remodeling
title_fullStr	MicroRNA biogenesis and regulation of bone remodeling
title_full_unstemmed	MicroRNA biogenesis and regulation of bone remodeling
title_sort	microrna biogenesis and regulation of bone remodeling
description	MicroRNAs (miRNAs) are key post-transcriptional regulators of gene expression. This review will highlight our current understanding of miRNA biogenesis and mechanisms of action, and will summarize recent work on the role of miRNAs, including the miR-29 family, in bone remodeling. These studies represent the first steps in demonstrating the importance of miRNAs in the control of osteoblast and osteoclast differentiation and function. An in-depth understanding of the roles of these regulatory RNAs in the skeleton will be critical for the development of new therapeutics aimed at treating bone loss and perhaps facilitating fracture repair.
publisher	BioMed Central
publishDate	2011
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3218876/
_version_	1611488425768124416

MicroRNA biogenesis and regulation of bone remodeling

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