Structural basis of the myosin X PH1N-PH2-PH1C tandem as a specific and acute cellular PI(3,4,5)P3 sensor
The first PH domain of the myosin X cargo-binding domain is split into halves by insertion of another PH domain forming a PH1N-PH2-PH1C tandem. This tandem forms a rigid supramodule with the two lipid-binding pockets juxtaposed for cooperative binding to PI(3,4,5)P3-containing lipid membranes.
| Main Authors: | , , , , |
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| Format: | Online |
| Language: | English |
| Published: |
The American Society for Cell Biology
2011
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3216653/ |