Efficacy and pharmacokinetic/pharmacodynamic evaluation of the Aurora kinase A inhibitor MLN8237 against preclinical models of pediatric cancer
Main Authors: | Carol, Hernan, Boehm, Ingrid, Reynolds, C. Patrick, Kang, Min H., Maris, John M., Morton, Christopher L., Gorlick, Richard, Kolb, E. Anders, Keir, Stephen T., Wu, Jianrong, Wozniak, Amy E., Yang, Yu, Manfredi, Mark, Ecsedy, Jeffrey, Wang, Jianmin, Neale, Geoffrey, Houghton, Peter J., Smith, Malcolm A., Lock, Richard B. |
---|---|
Format: | Online |
Language: | English |
Published: |
Springer-Verlag
2011
|
Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3215888/ |
Similar Items
-
The novel Aurora A kinase inhibitor MLN8237 is active in resistant chronic myeloid leukaemia and significantly increases the efficacy of nilotinib
by: Kelly, Kevin R, et al.
Published: (2011) -
MLN-8237: A dual inhibitor of aurora A and B in soft tissue sarcomas
by: Nair, Jayasree S., et al.
Published: (2016) -
Effect of Food on the Pharmacokinetics of the Investigational Aurora A Kinase Inhibitor Alisertib (MLN8237) in Patients with Advanced Solid Tumors
by: Falchook, Gerald S., et al.
Published: (2015) -
The Aurora-A inhibitor MLN8237 affects multiple mitotic processes and induces dose-dependent mitotic abnormalities and aneuploidy
by: Asteriti, Italia Anna, et al.
Published: (2014) -
Phase I study of MLN8237—investigational Aurora A kinase inhibitor—in relapsed/refractory multiple myeloma, Non-Hodgkin lymphoma and chronic lymphocytic leukemia
by: Kelly, Kevin R., et al.
Published: (2013)