Gold-silver alloy nanoshells: a new candidate for nanotherapeutics and diagnostics

We have developed novel gold-silver alloy nanoshells as magnetic resonance imaging (MRI) dual T1 (positive) and T2 (negative) contrast agents as an alternative to typical gadolinium (Gd)-based contrast agents. Specifically, we have doped iron oxide nanoparticles with Gd ions and sequestered the ions...

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Main Authors:	Gheorghe, Dana E, Cui, Lili, Karmonik, Christof, Brazdeikis, Audrius, Penaloza, Jose M, Young, Joseph K, Drezek, Rebekah A, Bikram, Malavosklish
Format:	Online
Language:	English
Published:	Springer 2011
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3212091/

id	pubmed-3212091
recordtype	oai_dc
spelling	pubmed-32120912011-11-09 Gold-silver alloy nanoshells: a new candidate for nanotherapeutics and diagnostics Gheorghe, Dana E Cui, Lili Karmonik, Christof Brazdeikis, Audrius Penaloza, Jose M Young, Joseph K Drezek, Rebekah A Bikram, Malavosklish Nano Express We have developed novel gold-silver alloy nanoshells as magnetic resonance imaging (MRI) dual T1 (positive) and T2 (negative) contrast agents as an alternative to typical gadolinium (Gd)-based contrast agents. Specifically, we have doped iron oxide nanoparticles with Gd ions and sequestered the ions within the core by coating the nanoparticles with an alloy of gold and silver. Thus, these nanoparticles are very innovative and have the potential to overcome toxicities related to renal clearance of contrast agents such as nephrogenic systemic fibrosis. The morphology of the attained nanoparticles was characterized by XRD which demonstrated the successful incorporation of Gd(III) ions into the structure of the magnetite, with no major alterations of the spinel structure, as well as the growth of the gold-silver alloy shells. This was supported by TEM, ICP-AES, and SEM/EDS data. The nanoshells showed a saturation magnetization of 38 emu/g because of the presence of Gd ions within the crystalline structure with r1 and r2 values of 0.0119 and 0.9229 mL mg-1 s-1, respectively (Au:Ag alloy = 1:1). T1- and T2-weighted images of the nanoshells showed that these agents can both increase the surrounding water proton signals in the T1-weighted image and reduce the signal in T2-weighted images. The as-synthesized nanoparticles exhibited strong absorption in the range of 600-800 nm, their optical properties being strongly dependent upon the thickness of the gold-silver alloy shell. Thus, these nanoshells have the potential to be utilized for tumor cell ablation because of their absorption as well as an imaging agent. Springer 2011-10-13 /pmc/articles/PMC3212091/ /pubmed/21995302 http://dx.doi.org/10.1186/1556-276X-6-554 Text en Copyright ©2011 Gheorghe et al; licensee Springer. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Gheorghe, Dana E Cui, Lili Karmonik, Christof Brazdeikis, Audrius Penaloza, Jose M Young, Joseph K Drezek, Rebekah A Bikram, Malavosklish
spellingShingle	Gheorghe, Dana E Cui, Lili Karmonik, Christof Brazdeikis, Audrius Penaloza, Jose M Young, Joseph K Drezek, Rebekah A Bikram, Malavosklish Gold-silver alloy nanoshells: a new candidate for nanotherapeutics and diagnostics
author_facet	Gheorghe, Dana E Cui, Lili Karmonik, Christof Brazdeikis, Audrius Penaloza, Jose M Young, Joseph K Drezek, Rebekah A Bikram, Malavosklish
author_sort	Gheorghe, Dana E
title	Gold-silver alloy nanoshells: a new candidate for nanotherapeutics and diagnostics
title_short	Gold-silver alloy nanoshells: a new candidate for nanotherapeutics and diagnostics
title_full	Gold-silver alloy nanoshells: a new candidate for nanotherapeutics and diagnostics
title_fullStr	Gold-silver alloy nanoshells: a new candidate for nanotherapeutics and diagnostics
title_full_unstemmed	Gold-silver alloy nanoshells: a new candidate for nanotherapeutics and diagnostics
title_sort	gold-silver alloy nanoshells: a new candidate for nanotherapeutics and diagnostics
description	We have developed novel gold-silver alloy nanoshells as magnetic resonance imaging (MRI) dual T1 (positive) and T2 (negative) contrast agents as an alternative to typical gadolinium (Gd)-based contrast agents. Specifically, we have doped iron oxide nanoparticles with Gd ions and sequestered the ions within the core by coating the nanoparticles with an alloy of gold and silver. Thus, these nanoparticles are very innovative and have the potential to overcome toxicities related to renal clearance of contrast agents such as nephrogenic systemic fibrosis. The morphology of the attained nanoparticles was characterized by XRD which demonstrated the successful incorporation of Gd(III) ions into the structure of the magnetite, with no major alterations of the spinel structure, as well as the growth of the gold-silver alloy shells. This was supported by TEM, ICP-AES, and SEM/EDS data. The nanoshells showed a saturation magnetization of 38 emu/g because of the presence of Gd ions within the crystalline structure with r1 and r2 values of 0.0119 and 0.9229 mL mg-1 s-1, respectively (Au:Ag alloy = 1:1). T1- and T2-weighted images of the nanoshells showed that these agents can both increase the surrounding water proton signals in the T1-weighted image and reduce the signal in T2-weighted images. The as-synthesized nanoparticles exhibited strong absorption in the range of 600-800 nm, their optical properties being strongly dependent upon the thickness of the gold-silver alloy shell. Thus, these nanoshells have the potential to be utilized for tumor cell ablation because of their absorption as well as an imaging agent.
publisher	Springer
publishDate	2011
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3212091/
_version_	1611486360131076096

Gold-silver alloy nanoshells: a new candidate for nanotherapeutics and diagnostics

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