Dissociation of Bone Resorption and Bone Formation in Adult Mice with a Non-Functional V-ATPase in Osteoclasts Leads to Increased Bone Strength

Dissociation of Bone Resorption and Bone Formation in Adult Mice with a Non-Functional V-ATPase in Osteoclasts Leads to Increased Bone Strength

Osteopetrosis caused by defective acid secretion by the osteoclast, is characterized by defective bone resorption, increased osteoclast numbers, while bone formation is normal or increased. In contrast the bones are of poor quality, despite this uncoupling of formation from resorption.

Bibliographic Details
Main Authors: Henriksen, Kim, Flores, Carmen, Thomsen, Jesper S., Brüel, Anne-Marie, Thudium, Christian S., Neutzsky-Wulff, Anita V., Langenbach, Geerling E. J., Sims, Natalie, Askmyr, Maria, Martin, Thomas J., Everts, Vincent, Karsdal, Morten A., Richter, Johan
Format: Online
Language:English
Published: Public Library of Science 2011
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3210177/

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3210177/

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