Cattle remain immunocompetent during the acute phase of foot-and-mouth disease virus infection

Infection of cattle with foot-and-mouth disease virus (FMDV) results in the development of long-term protective antibody responses. In contrast, inactivated antigen vaccines fail to induce long-term protective immunity. Differences between susceptible species have also been observed during infection...

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Main Authors:	Windsor, Miriam A, Carr, B Veronica, Bankowski, Bartomiej, Gibson, Debi, Reid, Elizabeth, Hamblin, Pip, Gubbins, Simon, Juleff, Nicholas, Charleston, Bryan
Format:	Online
Language:	English
Published:	BioMed Central 2011
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3207891/

id	pubmed-3207891
recordtype	oai_dc
spelling	pubmed-32078912011-11-04 Cattle remain immunocompetent during the acute phase of foot-and-mouth disease virus infection Windsor, Miriam A Carr, B Veronica Bankowski, Bartomiej Gibson, Debi Reid, Elizabeth Hamblin, Pip Gubbins, Simon Juleff, Nicholas Charleston, Bryan Research Infection of cattle with foot-and-mouth disease virus (FMDV) results in the development of long-term protective antibody responses. In contrast, inactivated antigen vaccines fail to induce long-term protective immunity. Differences between susceptible species have also been observed during infection with FMDV, with cattle often developing persistent infections whilst pigs develop more severe symptoms and excrete higher levels of virus. This study examined the early immune response to FMDV in naïve cattle after in-contact challenge. Cattle exposed to FMDV were found to be viraemic and produced neutralising antibody, consistent with previous reports. In contrast to previous studies in pigs these cattle did not develop leucopenia, and the proliferative responses of peripheral blood mononuclear cells to either mitogen or third party antigen were not suppressed. Low levels of type 1 interferon and IL-10 were detected in the circulation. Taken together, these results suggest that there was no generalised immunosuppression during the acute phase of FMDV infection in cattle. BioMed Central 2011 2011-10-20 /pmc/articles/PMC3207891/ /pubmed/22014145 http://dx.doi.org/10.1186/1297-9716-42-108 Text en Copyright ©2011 Windsor et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Windsor, Miriam A Carr, B Veronica Bankowski, Bartomiej Gibson, Debi Reid, Elizabeth Hamblin, Pip Gubbins, Simon Juleff, Nicholas Charleston, Bryan
spellingShingle	Windsor, Miriam A Carr, B Veronica Bankowski, Bartomiej Gibson, Debi Reid, Elizabeth Hamblin, Pip Gubbins, Simon Juleff, Nicholas Charleston, Bryan Cattle remain immunocompetent during the acute phase of foot-and-mouth disease virus infection
author_facet	Windsor, Miriam A Carr, B Veronica Bankowski, Bartomiej Gibson, Debi Reid, Elizabeth Hamblin, Pip Gubbins, Simon Juleff, Nicholas Charleston, Bryan
author_sort	Windsor, Miriam A
title	Cattle remain immunocompetent during the acute phase of foot-and-mouth disease virus infection
title_short	Cattle remain immunocompetent during the acute phase of foot-and-mouth disease virus infection
title_full	Cattle remain immunocompetent during the acute phase of foot-and-mouth disease virus infection
title_fullStr	Cattle remain immunocompetent during the acute phase of foot-and-mouth disease virus infection
title_full_unstemmed	Cattle remain immunocompetent during the acute phase of foot-and-mouth disease virus infection
title_sort	cattle remain immunocompetent during the acute phase of foot-and-mouth disease virus infection
description	Infection of cattle with foot-and-mouth disease virus (FMDV) results in the development of long-term protective antibody responses. In contrast, inactivated antigen vaccines fail to induce long-term protective immunity. Differences between susceptible species have also been observed during infection with FMDV, with cattle often developing persistent infections whilst pigs develop more severe symptoms and excrete higher levels of virus. This study examined the early immune response to FMDV in naïve cattle after in-contact challenge. Cattle exposed to FMDV were found to be viraemic and produced neutralising antibody, consistent with previous reports. In contrast to previous studies in pigs these cattle did not develop leucopenia, and the proliferative responses of peripheral blood mononuclear cells to either mitogen or third party antigen were not suppressed. Low levels of type 1 interferon and IL-10 were detected in the circulation. Taken together, these results suggest that there was no generalised immunosuppression during the acute phase of FMDV infection in cattle.
publisher	BioMed Central
publishDate	2011
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3207891/
_version_	1611485451230642176

Cattle remain immunocompetent during the acute phase of foot-and-mouth disease virus infection

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