In vivo microstructural and microvascular imaging of the human corneo-scleral limbus using optical coherence tomography

The corneo-scleral limbus contains several biological components, which are important constituents for understanding, diagnosing and managing several ocular pathologies, such as glaucoma and corneal abnormalities. An anterior segment optical coherence tomography (AS-OCT) system integrated with optic...

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Main Authors:	Li, Peng, An, Lin, Reif, Roberto, Shen, Tueng T., Johnstone, Murray, Wang, Ruikang K
Format:	Online
Language:	English
Published:	Optical Society of America 2011
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3207379/

id	pubmed-3207379
recordtype	oai_dc
spelling	pubmed-32073792011-11-10 In vivo microstructural and microvascular imaging of the human corneo-scleral limbus using optical coherence tomography Li, Peng An, Lin Reif, Roberto Shen, Tueng T. Johnstone, Murray Wang, Ruikang K Ophthalmology Applications The corneo-scleral limbus contains several biological components, which are important constituents for understanding, diagnosing and managing several ocular pathologies, such as glaucoma and corneal abnormalities. An anterior segment optical coherence tomography (AS-OCT) system integrated with optical microangiography (OMAG) is used in this study to non-invasively visualize the three-dimensional microstructural and microvascular properties of the limbal region. Advantages include first the ability to correct optical distortion of microstructural images enabling quantification of relationships in the anterior chamber angle. Second, microvascular images enable the visualization of the microcirculation in the limbal area without the use of exogenous contrast agents. Third, by combining the microstructural and microvascular information, the aqueous outflow pathway can be identified. The proposed AS-OCT can serve as a useful tool for ophthalmological research to determine normal and pathologic changes in the outflow system. As a clinical tool it has the potential to detect early aqueous outflow system abnormalities that lead to the pressure elevation in glaucoma. Recent surgical innovations and their implementations also rely on an assessment of outflow system structure and function, which can be revealed by AS-OCT. Optical Society of America 2011-10-18 /pmc/articles/PMC3207379/ /pubmed/22076271 http://dx.doi.org/10.1364/BOE.2.003109 Text en ©2011 Optical Society of America http://creativecommons.org/licenses/by-nc-nd/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-No Derivative Works 3.0 Unported License, which permits download and redistribution, provided that the original work is properly cited. This license restricts the article from being modified or used commercially.
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Li, Peng An, Lin Reif, Roberto Shen, Tueng T. Johnstone, Murray Wang, Ruikang K
spellingShingle	Li, Peng An, Lin Reif, Roberto Shen, Tueng T. Johnstone, Murray Wang, Ruikang K In vivo microstructural and microvascular imaging of the human corneo-scleral limbus using optical coherence tomography
author_facet	Li, Peng An, Lin Reif, Roberto Shen, Tueng T. Johnstone, Murray Wang, Ruikang K
author_sort	Li, Peng
title	In vivo microstructural and microvascular imaging of the human corneo-scleral limbus using optical coherence tomography
title_short	In vivo microstructural and microvascular imaging of the human corneo-scleral limbus using optical coherence tomography
title_full	In vivo microstructural and microvascular imaging of the human corneo-scleral limbus using optical coherence tomography
title_fullStr	In vivo microstructural and microvascular imaging of the human corneo-scleral limbus using optical coherence tomography
title_full_unstemmed	In vivo microstructural and microvascular imaging of the human corneo-scleral limbus using optical coherence tomography
title_sort	in vivo microstructural and microvascular imaging of the human corneo-scleral limbus using optical coherence tomography
description	The corneo-scleral limbus contains several biological components, which are important constituents for understanding, diagnosing and managing several ocular pathologies, such as glaucoma and corneal abnormalities. An anterior segment optical coherence tomography (AS-OCT) system integrated with optical microangiography (OMAG) is used in this study to non-invasively visualize the three-dimensional microstructural and microvascular properties of the limbal region. Advantages include first the ability to correct optical distortion of microstructural images enabling quantification of relationships in the anterior chamber angle. Second, microvascular images enable the visualization of the microcirculation in the limbal area without the use of exogenous contrast agents. Third, by combining the microstructural and microvascular information, the aqueous outflow pathway can be identified. The proposed AS-OCT can serve as a useful tool for ophthalmological research to determine normal and pathologic changes in the outflow system. As a clinical tool it has the potential to detect early aqueous outflow system abnormalities that lead to the pressure elevation in glaucoma. Recent surgical innovations and their implementations also rely on an assessment of outflow system structure and function, which can be revealed by AS-OCT.
publisher	Optical Society of America
publishDate	2011
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3207379/
_version_	1611485376078151680

In vivo microstructural and microvascular imaging of the human corneo-scleral limbus using optical coherence tomography

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