Protective Effect of Hypoxic Preconditioning on Hypoxic-Ischemic Injured Newborn Rats
Brief episodes of cerebral hypoxia-ischemia cause transient ischemic tolerance to subsequent ischemic events that are otherwise lethal. This study was conducted to evaluate the protective effect of hypoxic preconditioning on hypoxic-ischemic injury in the neonatal rat and the persistence of a protec...
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The Korean Academy of Medical Sciences
2011
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3207054/ |
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pubmed-32070542011-11-07 Protective Effect of Hypoxic Preconditioning on Hypoxic-Ischemic Injured Newborn Rats Park, Hyun-Kyung Seol, In-Joon Kim, Ki-Soo Original Article Brief episodes of cerebral hypoxia-ischemia cause transient ischemic tolerance to subsequent ischemic events that are otherwise lethal. This study was conducted to evaluate the protective effect of hypoxic preconditioning on hypoxic-ischemic injury in the neonatal rat and the persistence of a protective window after hypoxic preconditioning. The rats were preconditioned with hypoxia (8% oxygen, 92% nitrogen) for three hours, subjected to ischemia using ligation of the right common carotid artery, and then exposed to another three hours of hypoxia. Using proton magnetic resonance spectroscopy, terminal deoxynucleotidyl transferase-mediated dUTP-biotin nick end-labeling (TUNEL) staining, and morphologic scores, this study shows that hypoxic preconditioning 6-hr to 1-day before hypoxic-ischemic injury increases survival rates and has neuroprotective effects against subsequent hypoxic-ischemic injury. The mechanism of the protective effects of hypoxic preconditioning in the newborn rat brain may involve downregulation of apoptotic cell death. The Korean Academy of Medical Sciences 2011-11 2011-10-27 /pmc/articles/PMC3207054/ /pubmed/22065907 http://dx.doi.org/10.3346/jkms.2011.26.11.1495 Text en © 2011 The Korean Academy of Medical Sciences. http://creativecommons.org/licenses/by-nc/3.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
| repository_type |
Open Access Journal |
| institution_category |
Foreign Institution |
| institution |
US National Center for Biotechnology Information |
| building |
NCBI PubMed |
| collection |
Online Access |
| language |
English |
| format |
Online |
| author |
Park, Hyun-Kyung Seol, In-Joon Kim, Ki-Soo |
| spellingShingle |
Park, Hyun-Kyung Seol, In-Joon Kim, Ki-Soo Protective Effect of Hypoxic Preconditioning on Hypoxic-Ischemic Injured Newborn Rats |
| author_facet |
Park, Hyun-Kyung Seol, In-Joon Kim, Ki-Soo |
| author_sort |
Park, Hyun-Kyung |
| title |
Protective Effect of Hypoxic Preconditioning on Hypoxic-Ischemic Injured Newborn Rats |
| title_short |
Protective Effect of Hypoxic Preconditioning on Hypoxic-Ischemic Injured Newborn Rats |
| title_full |
Protective Effect of Hypoxic Preconditioning on Hypoxic-Ischemic Injured Newborn Rats |
| title_fullStr |
Protective Effect of Hypoxic Preconditioning on Hypoxic-Ischemic Injured Newborn Rats |
| title_full_unstemmed |
Protective Effect of Hypoxic Preconditioning on Hypoxic-Ischemic Injured Newborn Rats |
| title_sort |
protective effect of hypoxic preconditioning on hypoxic-ischemic injured newborn rats |
| description |
Brief episodes of cerebral hypoxia-ischemia cause transient ischemic tolerance to subsequent ischemic events that are otherwise lethal. This study was conducted to evaluate the protective effect of hypoxic preconditioning on hypoxic-ischemic injury in the neonatal rat and the persistence of a protective window after hypoxic preconditioning. The rats were preconditioned with hypoxia (8% oxygen, 92% nitrogen) for three hours, subjected to ischemia using ligation of the right common carotid artery, and then exposed to another three hours of hypoxia. Using proton magnetic resonance spectroscopy, terminal deoxynucleotidyl transferase-mediated dUTP-biotin nick end-labeling (TUNEL) staining, and morphologic scores, this study shows that hypoxic preconditioning 6-hr to 1-day before hypoxic-ischemic injury increases survival rates and has neuroprotective effects against subsequent hypoxic-ischemic injury. The mechanism of the protective effects of hypoxic preconditioning in the newborn rat brain may involve downregulation of apoptotic cell death. |
| publisher |
The Korean Academy of Medical Sciences |
| publishDate |
2011 |
| url |
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3207054/ |
| _version_ |
1611485306644594688 |