Unicentric mixed variant Castleman disease associated with Hashimoto disease: the role of PET/CT in staging and evaluating response to the treatment

Castleman disease (CD) is a rare atypical lymphoproliferative disease, pathologically classified as hyaline vascular, plasma cell type and mixed type variant. The underlying cause of CD is unknown, however several theories including autoimmunity have been proposed. We describe a patient diagnosed wi...

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Main Authors:	Akosman, Cengiz, Selcuk, Nalan Alan, Ordu, Cetin, Ercan, Sina, Ekici, Isin Dogan, Oyan, Basak
Format:	Online
Language:	English
Published:	e-Med 2011
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3205753/

id	pubmed-3205753
recordtype	oai_dc
spelling	pubmed-32057532013-06-15 Unicentric mixed variant Castleman disease associated with Hashimoto disease: the role of PET/CT in staging and evaluating response to the treatment Akosman, Cengiz Selcuk, Nalan Alan Ordu, Cetin Ercan, Sina Ekici, Isin Dogan Oyan, Basak Case Report Castleman disease (CD) is a rare atypical lymphoproliferative disease, pathologically classified as hyaline vascular, plasma cell type and mixed type variant. The underlying cause of CD is unknown, however several theories including autoimmunity have been proposed. We describe a patient diagnosed with unicentric mixed variant CD and Hashimoto thyroiditis, concurrently. She was staged with fluorodeoxyglucose (FDG)-positron emission tomography (PET)/computed tomography (CT) and the disease was localized to the mediastinum. After 6 cycles of chemotherapy consisting of vincristine and prednisone, the mediastinal lymph nodes regressed, but did not disappear from the CT scan. However, FDG-PET/CT showed complete metabolic response. Although the role of FDG-PET/CT in staging and evaluation of treatment response is controversial, this case shows that PET/CT can be effective and even better for staging and response evaluation. This case is also unique as there no case of CD in association with Hashimoto thyroiditis has been reported previously. However, the possibility of a coincidental association must be raised, especially when the high prevalence of Hashimoto thyroiditis is considered. e-Med 2011-06-15 /pmc/articles/PMC3205753/ /pubmed/21684830 http://dx.doi.org/10.1102/1470-7330.2011.0011 Text en © 2011 International Cancer Imaging Society
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Akosman, Cengiz Selcuk, Nalan Alan Ordu, Cetin Ercan, Sina Ekici, Isin Dogan Oyan, Basak
spellingShingle	Akosman, Cengiz Selcuk, Nalan Alan Ordu, Cetin Ercan, Sina Ekici, Isin Dogan Oyan, Basak Unicentric mixed variant Castleman disease associated with Hashimoto disease: the role of PET/CT in staging and evaluating response to the treatment
author_facet	Akosman, Cengiz Selcuk, Nalan Alan Ordu, Cetin Ercan, Sina Ekici, Isin Dogan Oyan, Basak
author_sort	Akosman, Cengiz
title	Unicentric mixed variant Castleman disease associated with Hashimoto disease: the role of PET/CT in staging and evaluating response to the treatment
title_short	Unicentric mixed variant Castleman disease associated with Hashimoto disease: the role of PET/CT in staging and evaluating response to the treatment
title_full	Unicentric mixed variant Castleman disease associated with Hashimoto disease: the role of PET/CT in staging and evaluating response to the treatment
title_fullStr	Unicentric mixed variant Castleman disease associated with Hashimoto disease: the role of PET/CT in staging and evaluating response to the treatment
title_full_unstemmed	Unicentric mixed variant Castleman disease associated with Hashimoto disease: the role of PET/CT in staging and evaluating response to the treatment
title_sort	unicentric mixed variant castleman disease associated with hashimoto disease: the role of pet/ct in staging and evaluating response to the treatment
description	Castleman disease (CD) is a rare atypical lymphoproliferative disease, pathologically classified as hyaline vascular, plasma cell type and mixed type variant. The underlying cause of CD is unknown, however several theories including autoimmunity have been proposed. We describe a patient diagnosed with unicentric mixed variant CD and Hashimoto thyroiditis, concurrently. She was staged with fluorodeoxyglucose (FDG)-positron emission tomography (PET)/computed tomography (CT) and the disease was localized to the mediastinum. After 6 cycles of chemotherapy consisting of vincristine and prednisone, the mediastinal lymph nodes regressed, but did not disappear from the CT scan. However, FDG-PET/CT showed complete metabolic response. Although the role of FDG-PET/CT in staging and evaluation of treatment response is controversial, this case shows that PET/CT can be effective and even better for staging and response evaluation. This case is also unique as there no case of CD in association with Hashimoto thyroiditis has been reported previously. However, the possibility of a coincidental association must be raised, especially when the high prevalence of Hashimoto thyroiditis is considered.
publisher	e-Med
publishDate	2011
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3205753/
_version_	1611484883692027904

Unicentric mixed variant Castleman disease associated with Hashimoto disease: the role of PET/CT in staging and evaluating response to the treatment

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