Is Ceftriaxone-Induced Biliary Pseudolithiasis Influenced by UDP-Glucuronosyltransferase 1A1 Gene Polymorphisms?

Ceftriaxone (cfx), a third-generation cephalosporin antibiotic, leads to transient cholelithiasis in some children, also known as pseudolithiasis. However, the underlying pathogenetic mechanism of this adverse effect has not yet been elucidated. We describe 3 children with ceftriaxone-induced pseudo...

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Main Authors:	Fretzayas, Andrew, Liapi, Olga, Papadopoulou, Anna, Nicolaidou, Polyxeni, Stamoulakatou, Alexandra
Format:	Online
Language:	English
Published:	Hindawi Publishing Corporation 2011
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3205720/

id	pubmed-3205720
recordtype	oai_dc
spelling	pubmed-32057202011-11-22 Is Ceftriaxone-Induced Biliary Pseudolithiasis Influenced by UDP-Glucuronosyltransferase 1A1 Gene Polymorphisms? Fretzayas, Andrew Liapi, Olga Papadopoulou, Anna Nicolaidou, Polyxeni Stamoulakatou, Alexandra Case Report Ceftriaxone (cfx), a third-generation cephalosporin antibiotic, leads to transient cholelithiasis in some children, also known as pseudolithiasis. However, the underlying pathogenetic mechanism of this adverse effect has not yet been elucidated. We describe 3 children with ceftriaxone-induced pseudolithiasis, who were also carriers of the A(TA)7TAA polymorphism of the UGT1A1 gene, implying that a cause and effect relation may exist. Hindawi Publishing Corporation 2011 2011-10-26 /pmc/articles/PMC3205720/ /pubmed/22110515 http://dx.doi.org/10.1155/2011/730250 Text en Copyright © 2011 Andrew Fretzayas et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Fretzayas, Andrew Liapi, Olga Papadopoulou, Anna Nicolaidou, Polyxeni Stamoulakatou, Alexandra
spellingShingle	Fretzayas, Andrew Liapi, Olga Papadopoulou, Anna Nicolaidou, Polyxeni Stamoulakatou, Alexandra Is Ceftriaxone-Induced Biliary Pseudolithiasis Influenced by UDP-Glucuronosyltransferase 1A1 Gene Polymorphisms?
author_facet	Fretzayas, Andrew Liapi, Olga Papadopoulou, Anna Nicolaidou, Polyxeni Stamoulakatou, Alexandra
author_sort	Fretzayas, Andrew
title	Is Ceftriaxone-Induced Biliary Pseudolithiasis Influenced by UDP-Glucuronosyltransferase 1A1 Gene Polymorphisms?
title_short	Is Ceftriaxone-Induced Biliary Pseudolithiasis Influenced by UDP-Glucuronosyltransferase 1A1 Gene Polymorphisms?
title_full	Is Ceftriaxone-Induced Biliary Pseudolithiasis Influenced by UDP-Glucuronosyltransferase 1A1 Gene Polymorphisms?
title_fullStr	Is Ceftriaxone-Induced Biliary Pseudolithiasis Influenced by UDP-Glucuronosyltransferase 1A1 Gene Polymorphisms?
title_full_unstemmed	Is Ceftriaxone-Induced Biliary Pseudolithiasis Influenced by UDP-Glucuronosyltransferase 1A1 Gene Polymorphisms?
title_sort	is ceftriaxone-induced biliary pseudolithiasis influenced by udp-glucuronosyltransferase 1a1 gene polymorphisms?
description	Ceftriaxone (cfx), a third-generation cephalosporin antibiotic, leads to transient cholelithiasis in some children, also known as pseudolithiasis. However, the underlying pathogenetic mechanism of this adverse effect has not yet been elucidated. We describe 3 children with ceftriaxone-induced pseudolithiasis, who were also carriers of the A(TA)7TAA polymorphism of the UGT1A1 gene, implying that a cause and effect relation may exist.
publisher	Hindawi Publishing Corporation
publishDate	2011
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3205720/
_version_	1611484865260158976

Is Ceftriaxone-Induced Biliary Pseudolithiasis Influenced by UDP-Glucuronosyltransferase 1A1 Gene Polymorphisms?

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