Graft-versus-host disease after kidney transplantation

Graft-versus-host disease (GVHD) is a rare complication after kidney transplantation. We describe a 62-year-old female with end-stage renal disease due to hypertension. She received a kidney with 4 mismatched human leukocyte antigen (HLA) out of 6 HLA - A, B, DR from a deceased donor. After the proc...

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Main Authors:	Kim, Jong Man, Kim, Sung Joo, Joh, Jae-Won, Kwon, Choon Hyuck David, Jang, Kee-Taek, An, Jungsuk, Ki, Chang-Seok, Kang, Eun-Suk, Shin, Milljae, Kim, Bok Nyeo, Lee, Suk-Koo
Format:	Online
Language:	English
Published:	The Korean Surgical Society 2011
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3205370/

id	pubmed-3205370
recordtype	oai_dc
spelling	pubmed-32053702011-11-07 Graft-versus-host disease after kidney transplantation Kim, Jong Man Kim, Sung Joo Joh, Jae-Won Kwon, Choon Hyuck David Jang, Kee-Taek An, Jungsuk Ki, Chang-Seok Kang, Eun-Suk Shin, Milljae Kim, Bok Nyeo Lee, Suk-Koo Case Report Graft-versus-host disease (GVHD) is a rare complication after kidney transplantation. We describe a 62-year-old female with end-stage renal disease due to hypertension. She received a kidney with 4 mismatched human leukocyte antigen (HLA) out of 6 HLA - A, B, DR from a deceased donor. After the procedure, the patient showed watery diarrhea on postoperative day (POD) 45. An endoscopic biopsy of the colon revealed some apoptotic cells consistent with GVHD. Thrombocytopenia was gradually developed on POD 54. She received steroid pulse therapy, and thrombocytopenia did not progress. However, pneumonia, renal failure, and cardiac failure occurred. She died due to multiple organ failure. We must consider GVHD in renal transplant recipients without homozygous or identical HLA, who had only watery diarrhea without other typical GVHD symptoms such as skin rash and fever, although GVHD is rare in renal transplant recipients. The Korean Surgical Society 2011-06 2011-06-17 /pmc/articles/PMC3205370/ /pubmed/22066080 http://dx.doi.org/10.4174/jkss.2011.80.Suppl1.S36 Text en Copyright © 2011, the Korean Surgical Society http://creativecommons.org/licenses/by-nc/3.0 Journal of the Korean Surgical Society is an Open Access Journal. All articles are distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Kim, Jong Man Kim, Sung Joo Joh, Jae-Won Kwon, Choon Hyuck David Jang, Kee-Taek An, Jungsuk Ki, Chang-Seok Kang, Eun-Suk Shin, Milljae Kim, Bok Nyeo Lee, Suk-Koo
spellingShingle	Kim, Jong Man Kim, Sung Joo Joh, Jae-Won Kwon, Choon Hyuck David Jang, Kee-Taek An, Jungsuk Ki, Chang-Seok Kang, Eun-Suk Shin, Milljae Kim, Bok Nyeo Lee, Suk-Koo Graft-versus-host disease after kidney transplantation
author_facet	Kim, Jong Man Kim, Sung Joo Joh, Jae-Won Kwon, Choon Hyuck David Jang, Kee-Taek An, Jungsuk Ki, Chang-Seok Kang, Eun-Suk Shin, Milljae Kim, Bok Nyeo Lee, Suk-Koo
author_sort	Kim, Jong Man
title	Graft-versus-host disease after kidney transplantation
title_short	Graft-versus-host disease after kidney transplantation
title_full	Graft-versus-host disease after kidney transplantation
title_fullStr	Graft-versus-host disease after kidney transplantation
title_full_unstemmed	Graft-versus-host disease after kidney transplantation
title_sort	graft-versus-host disease after kidney transplantation
description	Graft-versus-host disease (GVHD) is a rare complication after kidney transplantation. We describe a 62-year-old female with end-stage renal disease due to hypertension. She received a kidney with 4 mismatched human leukocyte antigen (HLA) out of 6 HLA - A, B, DR from a deceased donor. After the procedure, the patient showed watery diarrhea on postoperative day (POD) 45. An endoscopic biopsy of the colon revealed some apoptotic cells consistent with GVHD. Thrombocytopenia was gradually developed on POD 54. She received steroid pulse therapy, and thrombocytopenia did not progress. However, pneumonia, renal failure, and cardiac failure occurred. She died due to multiple organ failure. We must consider GVHD in renal transplant recipients without homozygous or identical HLA, who had only watery diarrhea without other typical GVHD symptoms such as skin rash and fever, although GVHD is rare in renal transplant recipients.
publisher	The Korean Surgical Society
publishDate	2011
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3205370/
_version_	1611484744116076544

Graft-versus-host disease after kidney transplantation

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