Phosphoproteomic mass spectrometry profiling links Src family kinases to escape from HER2 tyrosine kinase inhibition

Phosphoproteomic mass spectrometry profiling links Src family kinases to escape from HER2 tyrosine kinase inhibition

Despite the initial effectiveness of the tyrosine kinase inhibitor lapatinib against HER2 gene-amplified breast cancers, most patients eventually relapse after treatment, implying that tumors acquire mechanisms of drug resistance. To discover these mechanisms, we generated six lapatinib-resistant HE...

Full description

Bibliographic Details
Main Authors: Rexer, Brent N., Ham, Amy-Joan L., Rinehart, Cammie, Hill, Salisha, Granja-Ingram, Nara de Matos, González, Ana María, Mills, Gordon B., Dave, Bhuvanesh, Chang, Jenny C., Liebler, Daniel C., Arteaga, Carlos L.
Format: Online
Language:English
Published: 2011
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3204390/

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3204390/

Similar Items