Flavonoids in prevention of diseases with respect to modulation of Ca-pump function
Flavonoids, natural phenolic compounds, are known as agents with strong antioxidant properties. In many diseases associated with oxidative/nitrosative stress and aging they provide multiple biological health benefits. Ca2+-ATPases belong to the main calcium regulating proteins involved in the balanc...
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| Format: | Online |
| Language: | English |
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Slovak Toxicology Society SETOX
2011
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3203913/ |
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pubmed-32039132011-11-06 Flavonoids in prevention of diseases with respect to modulation of Ca-pump function Horáková, Lubica Review Article Flavonoids, natural phenolic compounds, are known as agents with strong antioxidant properties. In many diseases associated with oxidative/nitrosative stress and aging they provide multiple biological health benefits. Ca2+-ATPases belong to the main calcium regulating proteins involved in the balance of calcium homeostasis, which is impaired in oxidative/nitrosative stress and related diseases or aging. The mechanisms of Ca2+-ATPases dysfunction are discussed, focusing on cystein oxidation and tyrosine nitration. Flavonoids act not only as antioxidants but are also able to bind directly to Ca2+-ATPases, thus changing their conformation, which results in modulation of enzyme activity. Slovak Toxicology Society SETOX 2011-09 2011-09 /pmc/articles/PMC3203913/ /pubmed/22058652 http://dx.doi.org/10.2478/v10102-011-0019-5 Text en Copyright © 2011 Slovak Toxicology Society SETOX http://creativecommons.org/licenses/by/2.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
| repository_type |
Open Access Journal |
| institution_category |
Foreign Institution |
| institution |
US National Center for Biotechnology Information |
| building |
NCBI PubMed |
| collection |
Online Access |
| language |
English |
| format |
Online |
| author |
Horáková, Lubica |
| spellingShingle |
Horáková, Lubica Flavonoids in prevention of diseases with respect to modulation of Ca-pump function |
| author_facet |
Horáková, Lubica |
| author_sort |
Horáková, Lubica |
| title |
Flavonoids in prevention of diseases with respect to modulation of Ca-pump function |
| title_short |
Flavonoids in prevention of diseases with respect to modulation of Ca-pump function |
| title_full |
Flavonoids in prevention of diseases with respect to modulation of Ca-pump function |
| title_fullStr |
Flavonoids in prevention of diseases with respect to modulation of Ca-pump function |
| title_full_unstemmed |
Flavonoids in prevention of diseases with respect to modulation of Ca-pump function |
| title_sort |
flavonoids in prevention of diseases with respect to modulation of ca-pump function |
| description |
Flavonoids, natural phenolic compounds, are known as agents with strong antioxidant properties. In many diseases associated with oxidative/nitrosative stress and aging they provide multiple biological health benefits. Ca2+-ATPases belong to the main calcium regulating proteins involved in the balance of calcium homeostasis, which is impaired in oxidative/nitrosative stress and related diseases or aging. The mechanisms of Ca2+-ATPases dysfunction are discussed, focusing on cystein oxidation and tyrosine nitration. Flavonoids act not only as antioxidants but are also able to bind directly to Ca2+-ATPases, thus changing their conformation, which results in modulation of enzyme activity. |
| publisher |
Slovak Toxicology Society SETOX |
| publishDate |
2011 |
| url |
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3203913/ |
| _version_ |
1611484338021466112 |