The daily timing of gene expression and physiology in mammals
Mammalian behavior and physiology undergo daily rhythms that are coordinated by an endogenous circadian timing system. This system has a hierarchical structure, in that a master pacemaker, residing in the suprachiasmatic nucleus of the ventral hypothalamus, synchronizes peripheral oscillators in vi...
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| Format: | Online |
| Language: | English |
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Les Laboratoires Servier
2007
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3202490/ |
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pubmed-32024902011-10-27 The daily timing of gene expression and physiology in mammals Schibler, Ueli Basic Research Mammalian behavior and physiology undergo daily rhythms that are coordinated by an endogenous circadian timing system. This system has a hierarchical structure, in that a master pacemaker, residing in the suprachiasmatic nucleus of the ventral hypothalamus, synchronizes peripheral oscillators in virtually all body cells. While the basic molecular mechanisms generating the daily rhythms are similar in aIl cells, most clock out-puts are cell-specific. This conclusion is based on genomewide transcriptome profiling studies in several tissues that have revealed hundreds of rhythmically expressed genes. Cyclic gene expression in the various organs governs overt rhythms in behavior and physiology, encompassing sleep-wake cycles, metabolism, xenobiotic detoxification, and cellularproliferation. As a consequence, chronic perturbation of this temporal organization may lead to increased morbidity and reduced lifespan. Les Laboratoires Servier 2007-09 /pmc/articles/PMC3202490/ /pubmed/17969863 Text en Copyright: © 2007 LLS http://creativecommons.org/licenses/by-nc-nd/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by-nc-nd/3.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
| repository_type |
Open Access Journal |
| institution_category |
Foreign Institution |
| institution |
US National Center for Biotechnology Information |
| building |
NCBI PubMed |
| collection |
Online Access |
| language |
English |
| format |
Online |
| author |
Schibler, Ueli |
| spellingShingle |
Schibler, Ueli The daily timing of gene expression and physiology in mammals |
| author_facet |
Schibler, Ueli |
| author_sort |
Schibler, Ueli |
| title |
The daily timing of gene expression and physiology in mammals |
| title_short |
The daily timing of gene expression and physiology in mammals |
| title_full |
The daily timing of gene expression and physiology in mammals |
| title_fullStr |
The daily timing of gene expression and physiology in mammals |
| title_full_unstemmed |
The daily timing of gene expression and physiology in mammals |
| title_sort |
daily timing of gene expression and physiology in mammals |
| description |
Mammalian behavior and physiology undergo daily rhythms that are coordinated by an endogenous circadian timing system. This system has a hierarchical structure, in that a master pacemaker, residing in the suprachiasmatic nucleus of the ventral hypothalamus, synchronizes peripheral oscillators in virtually all body cells. While the basic molecular mechanisms generating the daily rhythms are similar in aIl cells, most clock out-puts are cell-specific. This conclusion is based on genomewide transcriptome profiling studies in several tissues that have revealed hundreds of rhythmically expressed genes. Cyclic gene expression in the various organs governs overt rhythms in behavior and physiology, encompassing sleep-wake cycles, metabolism, xenobiotic detoxification, and cellularproliferation. As a consequence, chronic perturbation of this temporal organization may lead to increased morbidity and reduced lifespan. |
| publisher |
Les Laboratoires Servier |
| publishDate |
2007 |
| url |
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3202490/ |
| _version_ |
1611483931926855680 |