Genetic Risk Factors for Longitudinal Changes in Structural MRI in Former Organolead Workers

This study examined associations between polymorphisms in three genes, apolipoprotein E (APOE), angiotensin converting enzyme (ACE), and vitamin D receptor (VDR), and longitudinal change in brain volumes and white matter lesions (WML) as well as effect modification by cardiovascular factors and tibi...

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Main Authors:	James, Bryan D., Caffo, Brian, Stewart, Walter F., Yousem, David, Davatzikos, Christos, Schwartz, Brian S.
Format:	Online
Language:	English
Published:	SAGE-Hindawi Access to Research 2011
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3199062/

id	pubmed-3199062
recordtype	oai_dc
spelling	pubmed-31990622011-10-25 Genetic Risk Factors for Longitudinal Changes in Structural MRI in Former Organolead Workers James, Bryan D. Caffo, Brian Stewart, Walter F. Yousem, David Davatzikos, Christos Schwartz, Brian S. Research Article This study examined associations between polymorphisms in three genes, apolipoprotein E (APOE), angiotensin converting enzyme (ACE), and vitamin D receptor (VDR), and longitudinal change in brain volumes and white matter lesions (WML) as well as effect modification by cardiovascular factors and tibia lead concentrations. Two MRIs, an average of 5 years apart, were obtained for 317 former organolead workers and 45 population-based controls. Both regions-of-interest and voxel-wise analyses were conducted. APOE ε3/ε4 and ε4/ε4 genotypes were associated with less decline in white matter volumes. There was some evidence of interaction between genetic polymorphisms and cardiovascular risk factors (ACE and high-density lipoprotein; VDR and diabetes) on brain volume decline. The VDR FokI ff genotype was associated with an increase in WML (no association for APOE or ACE). This study expands our understanding of how genetic precursors of dementia and cardiovascular diseases are related to changes in brain structure. SAGE-Hindawi Access to Research 2011 2011-10-18 /pmc/articles/PMC3199062/ /pubmed/22028967 http://dx.doi.org/10.4061/2011/362189 Text en Copyright © 2011 Bryan D. James et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	James, Bryan D. Caffo, Brian Stewart, Walter F. Yousem, David Davatzikos, Christos Schwartz, Brian S.
spellingShingle	James, Bryan D. Caffo, Brian Stewart, Walter F. Yousem, David Davatzikos, Christos Schwartz, Brian S. Genetic Risk Factors for Longitudinal Changes in Structural MRI in Former Organolead Workers
author_facet	James, Bryan D. Caffo, Brian Stewart, Walter F. Yousem, David Davatzikos, Christos Schwartz, Brian S.
author_sort	James, Bryan D.
title	Genetic Risk Factors for Longitudinal Changes in Structural MRI in Former Organolead Workers
title_short	Genetic Risk Factors for Longitudinal Changes in Structural MRI in Former Organolead Workers
title_full	Genetic Risk Factors for Longitudinal Changes in Structural MRI in Former Organolead Workers
title_fullStr	Genetic Risk Factors for Longitudinal Changes in Structural MRI in Former Organolead Workers
title_full_unstemmed	Genetic Risk Factors for Longitudinal Changes in Structural MRI in Former Organolead Workers
title_sort	genetic risk factors for longitudinal changes in structural mri in former organolead workers
description	This study examined associations between polymorphisms in three genes, apolipoprotein E (APOE), angiotensin converting enzyme (ACE), and vitamin D receptor (VDR), and longitudinal change in brain volumes and white matter lesions (WML) as well as effect modification by cardiovascular factors and tibia lead concentrations. Two MRIs, an average of 5 years apart, were obtained for 317 former organolead workers and 45 population-based controls. Both regions-of-interest and voxel-wise analyses were conducted. APOE ε3/ε4 and ε4/ε4 genotypes were associated with less decline in white matter volumes. There was some evidence of interaction between genetic polymorphisms and cardiovascular risk factors (ACE and high-density lipoprotein; VDR and diabetes) on brain volume decline. The VDR FokI ff genotype was associated with an increase in WML (no association for APOE or ACE). This study expands our understanding of how genetic precursors of dementia and cardiovascular diseases are related to changes in brain structure.
publisher	SAGE-Hindawi Access to Research
publishDate	2011
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3199062/
_version_	1611482699622514688

Genetic Risk Factors for Longitudinal Changes in Structural MRI in Former Organolead Workers

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