High-resolution imaging reveals indirect coordination of opposite motors and a role for LIS1 in high-load axonal transport

High-resolution particle tracking shows a specific role for the dynein regulatory factor LIS1 in high-load axonal transport of large vesicles but no evidence for mechanical activation of opposite-directed motors.

Bibliographic Details
Main Authors: Yi, Julie Y., Ori-McKenney, Kassandra M., McKenney, Richard J., Vershinin, Michael, Gross, Steven P., Vallee, Richard B.
Format: Online
Language:English
Published: The Rockefeller University Press 2011
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3198168/