A Genome-Wide Screen for Interactions Reveals a New Locus on 4p15 Modifying the Effect of Waist-to-Hip Ratio on Total Cholesterol

A Genome-Wide Screen for Interactions Reveals a New Locus on 4p15 Modifying the Effect of Waist-to-Hip Ratio on Total Cholesterol

Recent genome-wide association (GWA) studies described 95 loci controlling serum lipid levels. These common variants explain ∼25% of the heritability of the phenotypes. To date, no unbiased screen for gene–environment interactions for circulating lipids has been reported. We screened for variants th...

Full description

Bibliographic Details
Main Authors: Surakka, Ida, Isaacs, Aaron, Karssen, Lennart C., Laurila, Pirkka-Pekka P., Middelberg, Rita P. S., Tikkanen, Emmi, Ried, Janina S., Lamina, Claudia, Mangino, Massimo, Igl, Wilmar, Hottenga, Jouke-Jan, Lagou, Vasiliki, van der Harst, Pim, Mateo Leach, Irene, Esko, Tõnu, Kutalik, Zoltán, Wainwright, Nicholas W., Struchalin, Maksim V., Sarin, Antti-Pekka, Kangas, Antti J., Viikari, Jorma S., Perola, Markus, Rantanen, Taina, Petersen, Ann-Kristin, Soininen, Pasi, Johansson, Åsa, Soranzo, Nicole, Heath, Andrew C., Papamarkou, Theodore, Prokopenko, Inga, Tönjes, Anke, Kronenberg, Florian, Döring, Angela, Rivadeneira, Fernando, Montgomery, Grant W., Whitfield, John B., Kähönen, Mika, Lehtimäki, Terho, Freimer, Nelson B., Willemsen, Gonneke, de Geus, Eco J. C., Palotie, Aarno, Sandhu, Manj S., Waterworth, Dawn M., Metspalu, Andres, Stumvoll, Michael, Uitterlinden, André G., Jula, Antti, Navis, Gerjan, Wijmenga, Cisca, Wolffenbuttel, Bruce H. R., Taskinen, Marja-Riitta, Ala-Korpela, Mika, Kaprio, Jaakko, Kyvik, Kirsten O., Boomsma, Dorret I., Pedersen, Nancy L., Gyllensten, Ulf, Wilson, James F., Rudan, Igor, Campbell, Harry, Pramstaller, Peter P., Spector, Tim D., Witteman, Jacqueline C. M., Eriksson, Johan G., Salomaa, Veikko, Oostra, Ben A., Raitakari, Olli T., Wichmann, H.-Erich, Gieger, Christian, Järvelin, Marjo-Riitta, Martin, Nicholas G., Hofman, Albert, McCarthy, Mark I., Peltonen, Leena, van Duijn, Cornelia M., Aulchenko, Yurii S., Ripatti, Samuli
Format: Online
Language:English
Published: Public Library of Science 2011
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3197672/

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3197672/

Similar Items