Changes in Capsular Serotype Alter the Surface Exposure of Pneumococcal Adhesins and Impact Virulence

We examined the contribution of serotype on Streptococcus pneumoniae adhesion and virulence during respiratory tract infection using a panel of isogenic TIGR4 (serotype 4) mutants expressing the capsule types 6A (+6A), 7F (+7F) and 23F (+23F) as well as a deleted and restored serotype 4 (+4) control...

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Bibliographic Details
Main Authors: Sanchez, Carlos J., Hinojosa, Cecilia A., Shivshankar, Pooja, Hyams, Catherine, Camberlein, Emilie, Brown, Jeremy S., Orihuela, Carlos J.
Format: Online
Language:English
Published: Public Library of Science 2011
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3197518/