Tropomodulin Capping of Actin Filaments in Striated Muscle Development and Physiology

Tropomodulin Capping of Actin Filaments in Striated Muscle Development and Physiology

Efficient striated muscle contraction requires precise assembly and regulation of diverse actin filament systems, most notably the sarcomeric thin filaments of the contractile apparatus. By capping the pointed ends of actin filaments, tropomodulins (Tmods) regulate actin filament assembly, lengths,...

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Main Authors: Gokhin, David S., Fowler, Velia M.
Format: Online
Language:English
Published: Hindawi Publishing Corporation 2011
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3196151/
id pubmed-3196151
recordtype oai_dc
spelling pubmed-31961512011-10-19 Tropomodulin Capping of Actin Filaments in Striated Muscle Development and Physiology Gokhin, David S. Fowler, Velia M. Review Article Efficient striated muscle contraction requires precise assembly and regulation of diverse actin filament systems, most notably the sarcomeric thin filaments of the contractile apparatus. By capping the pointed ends of actin filaments, tropomodulins (Tmods) regulate actin filament assembly, lengths, and stability. Here, we explore the current understanding of the expression patterns, localizations, and functions of Tmods in both cardiac and skeletal muscle. We first describe the mechanisms by which Tmods regulate myofibril assembly and thin filament lengths, as well as the roles of closely related Tmod family variants, the leiomodins (Lmods), in these processes. We also discuss emerging functions for Tmods in the sarcoplasmic reticulum. This paper provides abundant evidence that Tmods are key structural regulators of striated muscle cytoarchitecture and physiology. Hindawi Publishing Corporation 2011 2011-10-17 /pmc/articles/PMC3196151/ /pubmed/22013379 http://dx.doi.org/10.1155/2011/103069 Text en Copyright © 2011 D. S. Gokhin and V. M. Fowler. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
repository_type Open Access Journal
institution_category Foreign Institution
institution US National Center for Biotechnology Information
building NCBI PubMed
collection Online Access
language English
format Online
author Gokhin, David S.
Fowler, Velia M.
spellingShingle Gokhin, David S.
Fowler, Velia M.
Tropomodulin Capping of Actin Filaments in Striated Muscle Development and Physiology
author_facet Gokhin, David S.
Fowler, Velia M.
author_sort Gokhin, David S.
title Tropomodulin Capping of Actin Filaments in Striated Muscle Development and Physiology
title_short Tropomodulin Capping of Actin Filaments in Striated Muscle Development and Physiology
title_full Tropomodulin Capping of Actin Filaments in Striated Muscle Development and Physiology
title_fullStr Tropomodulin Capping of Actin Filaments in Striated Muscle Development and Physiology
title_full_unstemmed Tropomodulin Capping of Actin Filaments in Striated Muscle Development and Physiology
title_sort tropomodulin capping of actin filaments in striated muscle development and physiology
description Efficient striated muscle contraction requires precise assembly and regulation of diverse actin filament systems, most notably the sarcomeric thin filaments of the contractile apparatus. By capping the pointed ends of actin filaments, tropomodulins (Tmods) regulate actin filament assembly, lengths, and stability. Here, we explore the current understanding of the expression patterns, localizations, and functions of Tmods in both cardiac and skeletal muscle. We first describe the mechanisms by which Tmods regulate myofibril assembly and thin filament lengths, as well as the roles of closely related Tmod family variants, the leiomodins (Lmods), in these processes. We also discuss emerging functions for Tmods in the sarcoplasmic reticulum. This paper provides abundant evidence that Tmods are key structural regulators of striated muscle cytoarchitecture and physiology.
publisher Hindawi Publishing Corporation
publishDate 2011
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3196151/
_version_ 1611481832228913152

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