Effects of Kynurenine Pathway Inhibition on NAD+ Metabolism and Cell Viability in Human Primary Astrocytes and Neurons
The kynurenine pathway (KP) is the principle route of L-Tryptophan (TRP) metabolism, producing several neurotoxic and neuroprotective metabolic precursors before complete oxidation to the essential pyridine nucleotide nicotinamide adenine dinucleotide (NAD+). KP inhibition may prove therapeutic in c...
| Main Authors: | , , |
|---|---|
| Format: | Online |
| Language: | English |
| Published: |
Libertas Academica
2011
|
| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3195218/ |