Knock-in reconstitution studies reveal an unexpected role of Cys-65 in regulating APE1/Ref-1 subcellular trafficking and function

Knock-in reconstitution studies reveal an unexpected role of Cys-65 in regulating APE1/Ref-1 subcellular trafficking and function

The multifunctional APE1 protein is required for tumor progression and is associated with cancer resistance. It is shown that APE1 presents structural elements that function in distinct cellular roles, highlighting the molecular determinants of the multifunctional nature of this protein and providin...

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Main Authors: Vascotto, Carlo, Bisetto, Elena, Li, Mengxia, Zeef, Leo A. H., D'Ambrosio, Chiara, Domenis, Rossana, Comelli, Marina, Delneri, Daniela, Scaloni, Andrea, Altieri, Fabio, Mavelli, Irene, Quadrifoglio, Franco, Kelley, Mark R., Tell, Gianluca
Format: Online
Language:English
Published: The American Society for Cell Biology 2011
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3192867/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3192867/

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