Epidemiology and Clinical Characteristics of Clostridium difficile Infection in a Korean Tertiary Hospital

In order to investigate the incidence, clinical and microbiologic characteristics of Clostridium difficile infection (CDI) in Korea, a prospective observational study was performed. From September 2008 through January 2010, all patients whose stool was tested for toxin assay A&B and/or C. diffic...

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Main Authors:	Kim, Jieun, Pai, Hyunjoo, Seo, Mi-ran, Kang, Jung Oak
Format:	Online
Language:	English
Published:	The Korean Academy of Medical Sciences 2011
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3192334/

id	pubmed-3192334
recordtype	oai_dc
spelling	pubmed-31923342011-10-21 Epidemiology and Clinical Characteristics of Clostridium difficile Infection in a Korean Tertiary Hospital Kim, Jieun Pai, Hyunjoo Seo, Mi-ran Kang, Jung Oak Original Article In order to investigate the incidence, clinical and microbiologic characteristics of Clostridium difficile infection (CDI) in Korea, a prospective observational study was performed. From September 2008 through January 2010, all patients whose stool was tested for toxin assay A&B and/or C. difficile culture were studied for clinical characteristics. Toxin types of the isolates from stool were tested. The mean incidence of CDI per 100,000 patient-days was 71.6 by month (range, 52.5-114.0), and the ratio of CDI to antibiotic-associated diarrhea was 0.23. Among 200 CDI patients, 37.5% (75/200) was severe CDI based on severity score. Clinical outcome of 189 CDI was as followed; 25.9% (49/189) improved without treatment, 84.3% (118/140) achieved clinical cure and attributed mortality was 0.7% (1/140) with the treatment. Recurrence rate was 21.4% (30/140) and cure without recurrence was 66.4% (93/140). The most common type of toxin was toxin A-positive/toxin B-positive strain (77.5%), toxin A-negative/toxin B-positive strains or binary toxin-producing strains comprised 15.4% or 7.1%, respectively. In conclusion, the incidence of CDI in Korea is a little higher than other reports during the non-epidemic setting. We expect that the change of epidemiology and clinical severity in CDI can be evaluated based on these results. The Korean Academy of Medical Sciences 2011-10 2011-10-01 /pmc/articles/PMC3192334/ /pubmed/22022175 http://dx.doi.org/10.3346/jkms.2011.26.10.1258 Text en © 2011 The Korean Academy of Medical Sciences. http://creativecommons.org/licenses/by-nc/3.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Kim, Jieun Pai, Hyunjoo Seo, Mi-ran Kang, Jung Oak
spellingShingle	Kim, Jieun Pai, Hyunjoo Seo, Mi-ran Kang, Jung Oak Epidemiology and Clinical Characteristics of Clostridium difficile Infection in a Korean Tertiary Hospital
author_facet	Kim, Jieun Pai, Hyunjoo Seo, Mi-ran Kang, Jung Oak
author_sort	Kim, Jieun
title	Epidemiology and Clinical Characteristics of Clostridium difficile Infection in a Korean Tertiary Hospital
title_short	Epidemiology and Clinical Characteristics of Clostridium difficile Infection in a Korean Tertiary Hospital
title_full	Epidemiology and Clinical Characteristics of Clostridium difficile Infection in a Korean Tertiary Hospital
title_fullStr	Epidemiology and Clinical Characteristics of Clostridium difficile Infection in a Korean Tertiary Hospital
title_full_unstemmed	Epidemiology and Clinical Characteristics of Clostridium difficile Infection in a Korean Tertiary Hospital
title_sort	epidemiology and clinical characteristics of clostridium difficile infection in a korean tertiary hospital
description	In order to investigate the incidence, clinical and microbiologic characteristics of Clostridium difficile infection (CDI) in Korea, a prospective observational study was performed. From September 2008 through January 2010, all patients whose stool was tested for toxin assay A&B and/or C. difficile culture were studied for clinical characteristics. Toxin types of the isolates from stool were tested. The mean incidence of CDI per 100,000 patient-days was 71.6 by month (range, 52.5-114.0), and the ratio of CDI to antibiotic-associated diarrhea was 0.23. Among 200 CDI patients, 37.5% (75/200) was severe CDI based on severity score. Clinical outcome of 189 CDI was as followed; 25.9% (49/189) improved without treatment, 84.3% (118/140) achieved clinical cure and attributed mortality was 0.7% (1/140) with the treatment. Recurrence rate was 21.4% (30/140) and cure without recurrence was 66.4% (93/140). The most common type of toxin was toxin A-positive/toxin B-positive strain (77.5%), toxin A-negative/toxin B-positive strains or binary toxin-producing strains comprised 15.4% or 7.1%, respectively. In conclusion, the incidence of CDI in Korea is a little higher than other reports during the non-epidemic setting. We expect that the change of epidemiology and clinical severity in CDI can be evaluated based on these results.
publisher	The Korean Academy of Medical Sciences
publishDate	2011
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3192334/
_version_	1611480394558865408

Epidemiology and Clinical Characteristics of Clostridium difficile Infection in a Korean Tertiary Hospital

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