Insulin-like growth factor binding protein-6 delays replicative senescence of human fibroblasts

Insulin-like growth factor binding protein-6 delays replicative senescence of human fibroblasts

► Proteomic analysis of senescent secretome reveals upregulation of IGFBP-6 in fibroblasts. ► IGFBP-6 knockdown induces premature senescence in young fibroblasts. ► IGFBP-6 lentiviral overexpression delays replicative senescence in fibroblasts.

Bibliographic Details
Main Authors: Micutkova, Lucia, Diener, Thomas, Li, Chen, Rogowska-Wrzesinska, Adelina, Mueck, Christoph, Huetter, Eveline, Weinberger, Birgit, Grubeck-Loebenstein, Beatrix, Roepstorff, Peter, Zeng, Rong, Jansen-Duerr, Pidder
Format: Online
Language:English
Published: Elsevier Science Ireland 2011
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3192261/

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3192261/

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