Platelet Adhesion and Degranulation Induce Pro-Survival and Pro-Angiogenic Signalling in Ovarian Cancer Cells

Thrombosis is common in ovarian cancer. However, the interaction of platelets with ovarian cancer cells has not been critically examined. To address this, we investigated platelet interactions in a range of ovarian cancer cell lines with different metastatic potentials [HIO-80, 59M, SK-OV-3, A2780,...

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Main Authors: Egan, Karl, Crowley, Darragh, Smyth, Paul, O'Toole, Sharon, Spillane, Cathy, Martin, Cara, Gallagher, Michael, Canney, Aoife, Norris, Lucy, Conlon, Niamh, McEvoy, Lynda, Ffrench, Brendan, Stordal, Britta, Keegan, Helen, Finn, Stephen, McEneaney, Victoria, Laios, Alex, Ducrée, Jens, Dunne, Eimear, Smith, Leila, Berndt, Michael, Sheils, Orla, Kenny, Dermot, O'Leary, John
Format: Online
Language:English
Published: Public Library of Science 2011
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3192146/