Noninvasive diagnosis of mucopolysaccharidosis via depth-resolved optical spectroscopy of the outer ear

Current diagnostics for lysosomal storage disorders such as mucopolysaccharidosis (MPS) rely on evaluation of ex vivo bodily fluids, which has several shortcomings. In this study, we evaluated whether Raman spectroscopy could noninvasively diagnose MPS in a murine model. Via confocal sampling of the...

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Bibliographic Details
Main Authors: Mittal, Richa, Schwartz, Philip H., Brick, David J., Lieber, Chad A.
Format: Online
Language:English
Published: Optical Society of America 2011
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3191441/